Advance your glycobiology research with our comprehensive suite of arrays. We offer a wide selection of formats, including lectin arrays for comprehensive glycan profiling, antibody arrays for targeted glycoprotein analysis, and custom arrays tailored to your specific research needs. Benefit from superior sensitivity and reproducibility, enabling the detection of even low-abundance glycans. Our arrays are designed for ease of use and streamlined workflows, minimizing hands-on time and maximizing data quality. Choose from pre-validated arrays for established applications or collaborate with our team to design custom arrays for novel research questions. Experience the power of precise glycan analysis and unlock new frontiers in glycobiology research and diagnostics.
Glycan arrays are indeed powerful tools for high-throughput analysis of glycan-protein and glycan-glycan interactions. These arrays consist of a diverse library of defined glycans covalently attached to a solid support, such as a glass slide or microarray chip, in a spatially defined arrangement
Key advantages of glycan arrays include:
Glycan arrays can incorporate various types of glycans, including N-glycans, O-glycans, and glycolipids, allowing for comprehensive profiling of the glycome1. The choice of array depends on factors such as attachment chemistry (e.g., NHS ester, amine coupling), glycan density, and the specific structures printed
Applications of glycan arrays include:
Glycan arrays provide quantitative data on binding affinities and specificities, enabling researchers to extract valuable information about glycan-protein interactions. This technology has significantly advanced the field of glycomics and continues to evolve, offering new insights into the complex world of carbohydrate biology
The glycan arrays help researchers:
Immobilized Molecule: Sugar Moieties (Glycans)Species Detected: Not species specific
Spot Replicates: Quadruplicate (Glycan 100)/Triplicate (Glycan 300)
Number of Targets: 100 or 300
Lectin arrays leverage the specific binding properties of lectins, carbohydrate-binding proteins, to profile the glycan composition of complex samples. Our lectin arrays offer a diverse collection of lectins with varying specificities for different glycan structures. This allows for a comprehensive analysis of the glycome, revealing subtle changes in glycosylation patterns associated with disease states or other biological processes. The high-throughput nature of our arrays enables rapid screening of multiple samples, significantly accelerating research. Data analysis is streamlined through our user-friendly software, providing clear visualizations and quantitative measurements of lectin-glycan interactions. This allows researchers to identify specific glycan biomarkers and gain insights into the roles of glycosylation in various biological contexts. The advantages include high throughput, sensitivity, and a broad glycan coverage, enabling detailed glycomic profiling in a variety of applications from disease diagnostics to fundamental glycobiology research.
Lectins are glycan-binding proteins which have been purified from trees, beans and some fruits. They are highly specific for a given glycan based on their sequence and the different sugar unit structures the glycan contains. The RayBiotech lectin arrays provide a powerful new tool for glycosylation determination, drug discovery and biomarker development; all with limited samples volumes required.
Immobilized Molecule: Lectins
Species Detected: Not species specific
Spot Replicates: Duplicate
Number of Targets: 70 or 95
Glycome Arrays allow researchers to efficiently obtain glycosylation profiles in their samples. Capture antibodies are printed onto glass slides and the glycans on these capture antibodies are removed. The glass slide arrays come pre-blocked and are ready to be incubated with samples. After incubation with samples and washing to remove unbound proteins, five unique biotin-labeled lectins are incubated with the array to allow binding to the glycans from captured target proteins. Streptavidin-conjugated fluorescent dye (Cy3 equivalent) is then added to the array. Finally, the glass slide is dried and laser fluorescence scanning is used to visualize the signals. These signals are then compared to the array map to identify glycosylated proteins present in the samples.
Immobilized Molecule: Antibodies
Species Detected: Human, mouse and rat
Spot Replicates: Duplicate
Number of Targets: up to 1000
| Size | 4 Sample Kit, 8 Sample Kit, 16 Sample Kit |
|---|---|
| Quantitative/Semi-Quantitative | Semi-Quantitative |
| Number of Targets Detected | 300 |
| Compatible Sample Types | Cell Culture Supernatants, Plasma, Serum, Tissue Lysates, Cell Lysates, Purified Proteins |
| Solid Support | Glass Slide |
| Method Of Detection | Fluorescence Laser Scanner |
| Design Principle | Sandwich-based, Label-based |
| Research Area | Post-Translational Modifications, Glycosylation |
| Estimated Lead Time | 1-2 business days |
| Shipping Type | Blue ice |
| Storage | -20°C |
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