Adonitol, Ribitol, CAS:488-81-3

Ribitol is a pentose sugar alcohol derived from ribose in vivo via the pentose phosphate pathway. It is a component of the glycopolymer teichoic acid in bacterial cell walls. Levels of ribitol are increased in the brain, cerebrospinal fluid, urine, and plasma of a patient with ribose-5-phosphate isomerase (RPI) deficiency, an extremely rare inborn error of metabolism characterized by a heterozygous frameshift mutation and missense allele in the RPI gene leading to leukoencephalopathy and mild peripheral polyneuropathy.
Title:?Adonitol
CAS Registry Number:?488-81-3CAS Name:?RibitolAdditional Names:?adoniteMolecular Formula:?C5H12O5Molecular Weight:?152.15Percent Composition:?C 39.47%, H 7.95%, O 52.58%Literature References:?A pentitol from?Adonis vernalis?L.,?Ranunculaceae;?also from?A. amurensis?L.,?Ranunculaceae:?Santavy, Reichstein,?Pharm. Acta Helv.?23,?153 (1948).Properties:?Large, optically inactive crystals. mp 102?. Does not reduce Fehling’s soln. Freely soluble in water, hot alcohol; insol in ether.Melting point:?mp 102?CAS Number488-81-3Product NameRibitolIUPAC Name(2S,4R)-pentane-1,2,3,4,5-pentolMolecular FormulaC5H12O5Molecular Weight152.15InChIInChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5?InChI KeyHEBKCHPVOIAQTA-ZXFHETKHSA-NSMILESC(C(C(C(CO)O)O)O)OSolubilitySoluble in DMSOSynonymsRibitol, Adonitol, NSC 16868
CAS No: 488-81-3 Synonyms: Adonitol MDL No: MFCD00064291 Chemical Formula: C5H12O5 Molecular Weight: 152.15IN Stock.??COA:Product name:?Adonitol?Ribitol???CAS:?488-81-3? ??M.F.: C5H12O5? ? ? ??M.W.:?152.15ItemsStandardsResultsAppearanceA white solidPositiveSolubilityEasily soluble in H2O andless soluble in petroleum etherCompliesAppearance of solutionDissolve 0.5 gin 10 ml of water,and the solution should be clearCompliesNMR and ESI-MSShould complyCompliesIdentificationIR and TLCPositiveM.P.100??- 102?100??- 102?Residue on ignitionMax. 0.5%0.05%Heavy metalMax. 20ppmCompliesTLC?(15%H2SO4-C2H5OH)One spotCompliesAssayMin. 98%99.2%References:
1. de Vald?z GF, de Giori GS, de Ruiz Holgado AAP, Oliver G, Appl. Environ. Microbiol. 1983, p302?304