Gangliotriose , N-Acetylgalactosamine b1-4 Lactose

Gangliotriose ,?N-Acetylgalactosamine b1-4 Lactose,Asialo-GM2-trisaccharide ;?Asialo GM2 oligosaccharide;?GalNAc(b1-4)Gal(b1-4)Glc
Gangliotriose is the core trisaccharide structure in gangliosides, such as, GD2 (GalNAcβ1,4Galβ1,4Glc) (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that posess: self-renewal properties (division without disrupting the undifferentiated state), and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).CAS No1355005-58-1SynonymsAsialo-GM2-trisaccharideN-Acetylgalactosamine b1-4 LactoseAsialo GM2 oligosaccharideGalNAc(b1-4)Gal(b1-4)GlcChemical FormulaC20H35NO16Molecular Weight545.49 g/molSmilesCC(=O)NC1[C@@H](O)[C@@H](O)C(CO)O[C@H]1O[C@@H]2[C@H](O)C(O)[C@H](O[C@H]3[C@H](O)C(O)C(O)OC3CO)OC2COStoragestore at 10?C – 25?CHarmonized Tariff CodesSwitzerland: 29400010 – USA: 2940006000 – Slovakia: 2940000010 – UK: 2940000000 – China: 2940000000