Request a quote
Catalog No: A10GD-4460
Cas No: 206443-06-3
Properties: Mol Formula: C16H18NaO11S, Mol Weight: 441.4
IUPAC Name: sodium;[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-2-yl]methyl sulfate
Synonym: Sodium, [(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-2-yl]methyl sulfate, 4-Methylumbelliferyl-|A-D-galactopyranoside 6-sulfate (sodium)
A substrate used for the diagnosis of Morquio disease type A.
4-Methylumbelliferyl ?-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity. 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient. 4-MU-Gal-6S can be used to assess GALNS activity in a very small blood volume to determine the extent of deficiency.
| CAS Number | 206443-06-3 |
| Product Name | Sodium;[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-2-yl]methyl sulfate |
| IUPAC Name | sodium;[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-2-yl]methyl sulfate |
| Molecular Formula | C16H17NaO11S |
| Molecular Weight | 440.4 |
| InChI | InChI=1S/C16H18O11S.Na/c1-7-4-12(17)26-10-5-8(2-3-9(7)10)25-16-15(20)14(19)13(18)11(27-16)6-24-28(21,22)23;/h2-5,11,13-16,18-20H,6H2,1H3,(H,21,22,23);/q;+1/p-1/t11-,13+,14+,15-,16-;/m1./s1 |
| InChI Key | KHTOBGQRIASILC-XNSOHGFJSA-M |
| SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)COS(=O)(=O)[O-])O)O)O.[Na+] |
| Synonyms | 4-Methyl-7-[(6-O-sulfo-?-D-galactopyranosyl)oxy]-2H-1-benzopyran-2-one Monosodium Salt; |
| Size | 1 G, 100 MG, 5 G, Other |
|---|
10 in stock
IUPAC:Gal?1-4GlcNAc?1-3Gal?1-4GlcNAc?1-3Gal?1-4Glc, G84034JH
10 in stock
10 in stock
10 in stock
Glycodepot serve all your needs in glycoscience from products, services, networking and announcements. Get the best glycoscience products and services to support your research. Shop Now and learn about cutting-edge solutions in glycochemistry, glycobiology, and glyco-analysis!
