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Catalog No: A10GD-4678
Cas No: 62480-44-8
Properties: Mol Formula: C16H21ClN2O3, Mol Weight: 324.8
IUPAC Name: (2S)-2-amino-4-methyl-N-(4-methyl-2-oxochromen-7-yl)pentanamide;hydrochloride
Synonym: L-Leucine-7-amido-4-methylcoumarin hydrochloride, H-L-LEU-AMC HCL, (S)-2-amino-4-methyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanamide hydrochloride
L-Leucine (4-methyl-7-coumarinylamide) hydrochloride; H-Leu-AMC ? HCl
Fluorogenic substrate for leucine aminopeptidase.
L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase. Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
L-Leucine 7-Amido-4-methylcoumarin Hydrochloride is a fluorogenic substrate for LAP3 (leucine aminopeptidase). Upon enzyme activity, a bright blue fluorescent dye, 7-amino-4-methylcoumarin, is released.
L-Leucine 7-amido-4-methylcoumarin hydrochloride salt is a protease inhibitor that has been shown to inhibit the activity of serine proteases. It has been shown to have potential as a drug target, and has also been shown to be effective in wastewater treatment. The biochemical properties of L-Leucine 7-amido-4-methylcoumarin hydrochloride salt have been investigated using sephadex G-100 chromatography and phosphatase activity assays. This molecule has also been shown to affect physiological function and enzyme activities in rats. L-Leucine 7-amido-4-methylcoumarin hydrochloride salt is metabolized by microbial enzymes, such as proteases, which may produce ATP as an energy source.
| CAS Number | 62480-44-8 |
| Product Name | L-Leucine-7-amido-4-methylcoumarin hydrochloride |
| IUPAC Name | (2S)-2-amino-4-methyl-N-(4-methyl-2-oxochromen-7-yl)pentanamide;hydrochloride |
| Molecular Formula | C16H20N2O3*HCl |
| Molecular Weight | 324,8 g/mole |
| InChI | InChI=1S/C16H20N2O3.ClH/c1-9(2)6-13(17)16(20)18-11-4-5-12-10(3)7-15(19)21-14(12)8-11;/h4-5,7-9,13H,6,17H2,1-3H3,(H,18,20);1H/t13-;/m0./s1 |
| SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC(C)C)N.Cl |
| Size | 1 G, 100 MG, 5 G, Other |
|---|
IUPAC:Gal?1-4GlcNAc?1-3Gal?1-4GlcNAc?1-3Gal?1-4Glc, G84034JH
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