UDP-4-F-D-Glc.2 Na

UDP-4-F-D-Glc.2 Na

UDP-4-F-D-Glucose
UDP-4-F-D-Glc.2Na, Uridine 5?-disphospho-4-F-D-glucose disodium salt

UDP-4-F-D-Glc.2 Na (Uridine Diphosphate 4-Fluoro-D-Glucose disodium salt) is a fluorinated nucleotide sugar involved in the synthesis of glycosylated compounds. It is a derivative of UDP-Glucose where the hydroxyl group at the 4-position is replaced by a fluorine atom, giving it distinct chemical and biological properties.

Structure & Properties:

• Molecular Weight (MW): Approximately 586 g/mol (depending on the specific form and substitutions)
• Chemical Formula: C15H22FNO17P2Na2 (approximate)
• Synonyms: UDP-4-fluoro-D-glucose, Uridine Diphosphate 4-fluoro-D-glucose disodium salt
• Functional Groups: This molecule includes a fluorine atom at the 4-position of the glucose moiety, a notable modification that affects its chemical reactivity and interactions in biological systems.

Biological Role:

• Biosynthesis Pathway: UDP-4-F-D-Glc is synthesized from UDP-glucose via fluorination at the 4-position. It serves as a sugar donor in the glycosylation processes that occur in cells.
• Function: This modified sugar is often used in biochemical research for studying glycosylation mechanisms or for developing synthetic glycan analogs with altered biological properties.

Applications:

• Glycosylation Research: UDP-4-F-D-Glc is used in research focusing on glycosylation pathways and enzyme-substrate interactions. The incorporation of fluorine allows for the investigation of specific glycan biosynthesis processes.
• Drug Development: The fluorinated sugar nucleotide may be employed in drug design, particularly in the development of enzyme inhibitors or glycomimetics that mimic the action of natural sugars but with enhanced stability or altered biological activity.

Research Significance:

• Fluorinated Sugar Nucleotides: The introduction of fluorine in biological molecules can enhance stability and resist enzymatic degradation. UDP-4-F-D-Glc is valuable for exploring the effects of fluorinated sugars in cellular processes.
• Therapeutic Potential: Studying the interactions of fluorinated sugars with glycosylation enzymes could lead to new insights into the development of therapeutic agents, particularly in the fields of oncology and infectious disease.

Storage and Stability:

• Storage: Store UDP-4-F-D-Glc at -20°C in a moisture-free environment.
• Stability: The compound is stable under recommended storage conditions but should be protected from exposure to light and moisture to prevent degradation.

Research Areas:

• Enzyme Mechanisms: UDP-4-F-D-Glc is used to probe the specificity and mechanisms of glycosyltransferases involved in sugar modification and glycan biosynthesis.
• Synthetic Glycobiology: Researchers use this fluorinated nucleotide sugar to create novel glycan structures that may have therapeutic or diagnostic applications in biotechnology and medicine.

This fluorinated sugar nucleotide represents a powerful tool in the study of glycosylation and its applications in biomedical research.