In the modern era, consumers are gradually shifting focus to the use of natural ingredients to achieve good health, beauty, and general well-being1. Salidroside has been a target buzzword in research and product development alongside many other bioactive compounds. Salidroside originally was found in Rhodiola rosea, a traditional adaptogenic herb, but due to the current […]
Hydroxy salidroside is beginning to be one of the most promising natural products in contemporary health sciences1. This phenylethanoid glycoside is structurally analogous to salidroside except that it has an extra hydroxyl group that augments its antioxidant, neuroprotective, and anti-ageing effects. Hydroxy salidroside traditionally is a product of plants, but, more recently, has also been […]
Glycans are polysaccharides or complex groups of sugars attached to the outside of our cells, secreted proteins and lipids, and secreted in body fluids such as saliva, milk, and mucus1. These structures of carbohydrates are not simple ornaments. When positioned in highly specific standard forms, they constitute the blood group antigens most of us know […]
Antibody-Drug Conjugates (ADCs) are reshaping modern cancer treatment by offering a more targeted and efficient way to fight tumors¹. Contrary to conventional chemotherapy, which moves to all parts of the body, damaging all healthy and cancerous cells, ADCs target the entire procedure in a surgically correct way. This has made them significantly less harmful to […]
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found in connective tissues of the body, especially in the skin, joints, eyes, as well as the extracellular matrix. Due to its spectacular capacity to hold a lot of water, HA has very strong moisturizing and viscoelastic properties, and it is therefore essential in skin hydration, the […]
What Are Glycan Arrays? Glycan arrays or carbohydrate microarrays are special-purpose analysis instruments used to investigate carbohydrate (glycan)-specific interactions with different proteins or carbon and biological targets1. Similar to DNA microarrays or protein microarrays, a glycan array is a solid support (in most cases, a slide made of glass, but also a microplate) where a […]
Glycoprofiling: Unlocking the Secrets of Glycobiology Introduction Glycoprofiling is an important method of analysis in the fast-developing area of glycobiology. It concerns the characterization and study in detail of the structures of glycans, complex carbohydrates that bind to proteins and lipids by covalent bonds. Such glycan changes are much more than attractive; actually, they are […]
UGT-Assisted Glycosylation in Drug Discovery: Unlocking Potential with GlycoDepot’s 386 Enzyme Library Introduction Enzyme-based glycosylation, in which a sugar chain is conjugated to a small molecular compound, is becoming a transformative technology in present-day drug discovery. It is a biochemical transformation that may enhance the pharmacokinetic and pharmacodynamic characteristics of a drug candidate, including solubility, […]
What are Carbohydrates? Carbohydrates are an important class of (Glycosaminoglycans) biomolecules containing carbon, hydrogen, and oxygen as the main components, with the general stoichiometry of (CH₂O)n. Carbohydrates provide the primary source of energy essential for life, and they also have important structural roles. Carbohydrates are present in almost all living things and include simple sugars […]
Human milk oligosaccharides (HMOs) are the third most abundant solid human breast milk component behind lactose and lipids, and occur in total concentrations during colostrum of about 20 25 g/L and mature milk of 5 15g /L as reported by several studies, including a 2020 cohort analysis by Pediatric Research. This group of non-digestible carbohydrates […]
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