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Glycobiology is a branch of molecular biology that studies the structure, biosynthesis, and biological functions of carbohydrates (glycans) and their interactions with other molecules in biological systems. It plays a crucial role in understanding the intricate roles that carbohydrates play in various physiological and pathological processes. Here are key aspects of glycobiology:
Glycans and Glycoproteins:
Definition: Glycans are complex carbohydrates composed of sugar molecules linked together. Glycoproteins are proteins with attached glycans.
Function: They are involved in cell signaling, adhesion, immune response, and various cellular recognition processes.
Glycosylation:
Process: Glycosylation is the enzymatic process of attaching glycans to proteins, lipids, or other organic molecules.
Types: N-linked and O-linked glycosylation are common types, occurring in the endoplasmic reticulum and Golgi apparatus.
Cellular Recognition and Signaling:
Role: Glycans on cell surfaces participate in recognition events between cells, facilitating processes such as immune response and embryonic development.
Lectins: Proteins that specifically bind to glycans, called lectins, play a key role in cellular recognition.
Diseases and Glycobiology:
Cancer: Altered glycosylation is associated with cancer progression and metastasis.
Genetic Disorders: Defects in glycan synthesis or processing can lead to genetic disorders known as congenital disorders of glycosylation (CDGs).
Glycomics:
Definition: Glycomics is the systematic study of the entire complement of glycans in a cell or organism.
Techniques: Mass spectrometry, nuclear magnetic resonance (NMR), and chromatography are used for glycomic analysis.
Glycoengineering:
Definition: Glycoengineering involves modifying glycan structures on cells or proteins for specific purposes.
Applications: Used in the development of therapeutic proteins, vaccines, and improving the efficacy of biopharmaceuticals.
Glycan-Binding Proteins:
Lectins: Proteins that recognize and bind to specific glycans, serving as tools for studying glycan structures and functions.
Role: Used in various biological assays and diagnostic applications.
Glycobiology in Drug Development:
Targets: Glycans and glycan-binding proteins are potential targets for drug development.
Therapeutic Strategies: Drugs targeting glycan-related processes are being explored for treating diseases such as cancer and infectious diseases.
Glycoconjugates:
Definition: Molecules formed by the combination of a glycan with a non-carbohydrate entity, such as a protein or lipid.
Biological Significance: Play roles in cellular recognition, signaling, and immune response.
Glycobiology is a dynamic field that continues to reveal the importance of carbohydrates in the complexity of biological systems. Understanding the roles of glycans contributes to advancements in medicine, diagnostics, and biotechnology.
Catalog No.: ? A1SE-3020
E.C. : 3.2.1.111
Product Details: E.coli recombinant 1,3-1,4-alpha-L-fucosidase from Bifidobacterium bifidum.
Unit Definition : ?One unit is defined as the amount of enzyme that catalyzes? the formation of 1 ?mo Gal?1-4GlcNAc from Gal?1-4(Fuc?1-3) GlcNAc minute at 45?,pH 6.0.
Package : ? 1 U, 5 U, 25 U
10 in stock
Catalog No.: ? A1SE-3015
E.C. : 3.2.1.123
Product Details: ??-galactosidase catalyzes the hydrolysis of Gal?1,4Glc,E. coli recombinant ?-galactosidase from E. coli
Unit Definition : ??One unit is defined as the amount of enzyme that catalyzes the hydrolysis of 1 ?mol Gal?1,4Glc per minute at 37?
Package : ? 100U, 1000 U
10 in stock
Catalog No.: ? A1SE-3017
E.C. : 3.2.1.111
Product Details: ?? 1-2 fucosidase catalyzes the hydrolysis of ? 1-2 linked fucose residues from Fuc?1,2Gal?1,4Glc,E. coli?recombinant ? 1-2 fucosidase from Bifidobacterium bifidum
Unit Definition : ??One unit is defined as the amount of enzyme that catalyzes the hydrolysis of 1 ?mol Fuc?1,2Gal?1,4Glc per minute at 37?C
Package : ? 1 U, 10 U
10 in stock
Catalog No.: ? A1SE-1019
E.C. : 2.4.1.69
Product Details: E. coli recombinant ?1, 2-fucosyltransferase from Helicobacter pylori
Unit Definition : ??One unit is defined as the amount of enzyme that transfer 1?mol fucose from GDP-Fuc to lactose to form Fuc?1,2Lac per min at 37?C
Package : ? 1 U, 5 U, 25 U
10 in stock
Catalog No.: ? A1SE-1018
E.C. : 2.4.1.65
Product Details: E. coli recombinant ?1, 3-fucosyltransferase from Helicobacter pylori
Unit Definition : ??One unit is defined as the amount of enzyme that transfer 1?mol fucose from GDP-Fuc to Gal ?1-4GlcNAc to form Fuc?1,3(Gal ?1-4)GlcNAc per min at 37?C
Package : ? 1 U, 5 U
10 in stock
Catalog No.: ? A1SE-1012
E.C. : 2.4.1.86
Product Details: E. coli recombinant ?1, 3-galactosyltransferase from Escherichia coli O55:H7
Unit Definition : ??One unit is defined as the amount of enzyme that transfer 1?mol Gal from UDPGal to GlcNAcOR to form Gal?1,3GlcNAcOR per min at 37?C
Package : ? 10 U, 100 U, 1000 U
10 in stock
Catalog No.: ? A1SE-3016
E.C. : 3.2.1.111
Product Details: ??1,3/4-fucosidase catalyzes the hydrolysis of ?1,3-linked fucose residues from Gal?1,4(Fuc?1,3)Glc,E. coli?recombinant ?1,3/4-fucosidase from Bifidobacterium bifidum
Unit Definition : ??One unit is definedas the amount of enzyme that catalyzes the hydrolysis of 1 ?mol Gal?1,4(Fuc?1,3)Glc per minute at 37?C
Package : ? 1U, 10 U
10 in stock
Catalog No.: ? A1SE-1020
E.C. : 2.4.1.65
Product Details: E. coli recombinant ?1, 3/4-fucosyltransferase from Helicobacter pylori.
Unit Definition : ??One unit is defined as the amount of enzyme that catalyzes the transfer of 1?mol fucose from GDP-Fuc to acceptor per minute at 37?C.
Package : ? 10 mU, 100 mU
10 in stock
Catalog No.: ? A1SE-1008
E.C. : 2.4.1.87
Product Details: E. coli recombinant ?1, 3-galactosyltransferase from Bovine
Unit Definition : ??One unit is defined as the amount of enzyme that transfer 1 ?mol Gal from UDP-Gal to Gal?1,4GlcOR to form Gal?1,3Gal?1,4GlcOR per min at 37?C
Package : ? 100 mU, 1 U, 5 U
10 in stock
Catalog No.: ? A1SE-4011
E.C. : 3.2.1.51
Product Details: Exoglycosidases capable of cleaving? 1, 6 linked L-fucose residues from fucosyloligosaccharides, E.coli?recombinant ? 1, 6-fucosidase from Lactobacillus casei
Unit Definition : ?One unit is defined as the amount of enzyme that catalyzes the formation of 1 ?mol GlcNAc-peptides from Fuc?1, 6GlcNAcpeptides per minute at 37?C
Package : ? 1 U, 5 U, 10 U
10 in stock
Catalog No.: ? A1SE-1027
E.C. : 2.4.1.69
Product Details: E.coli recombinant ?1,2-fucosyltransferase from E.coli O126.
Unit Definition : ? One unit is defined as the amount of enzyme that transfer 1?mol Fucose from GDP-Fuc to lactose to form Fuc?1, 2Lac per min at 37?C.
Package : ? 100 mU, 1 U
10 in stock
Catalog No.: ? A1SE-1021
E.C. : 2.4.1.62
Product Details: E. coli recombinant ?1,3-galactosyltransferase from Chromobacterium violaceum.
Unit Definition : ??One unit is defined as the amount of enzyme that catalyzes the transfer of 1 ?mol gal from UDP-Gal to GlcNAc?3Gal?4Glc per minute at 37?C.
Package : ? 10 mU, 100 mU
10 in stock
Catalog No.: ? A1SE-1026
E.C. : 2.4.1.62
Product Details: E.coli recombinant ?1,3-galactosyltransferase from Pseudogulbenkiania ferrooxidans.
Unit Definition : ??One unit is defined as the amount of enzyme that catalyzes the transfer of 1 ?mol gal from UDP-Gal to GlcNAc?3Gal?4Glc per minute at 37?C.
Package : ? 10 mU, 100 mU
10 in stock
Catalog No.: ? A1SE-1023
E.C. : 2.4.1.56
Product Details: E. coli recombinant ?1,3-N-acetylglucosaminyltransferase from Helicobacter pylori.
Unit Definition : ??One unit is defined as the amount of enzyme that catalyzes the transfer of 1 ?mol gal from UDP-GlcNAc to Gal?4GlcNAc per minute at 37?C.
Package : ? 10 mU, 100 mU
10 in stock
Catalog No.: ? A1SE-1022
E.C. : 2.4.1.22
Product Details: E. coli recombinant ?1,4-Galactosyltransferase from Helicobacter pylori.
Unit Definition : ??One unit is defined as the amount of enzyme that catalyzes the transfer of 1 ?mol gal from UDP-Gal to GlcNAc per minute at 37?C.
Package : ? 10 mU, 100 mU
10 in stock
Catalog No.: ? A1SE-1017
E.C. : 2.4.99.4
Product Details: E. coli recombinant ?2, 3-sialyltransferase from Photobacterium phosphoreum
Unit Definition : ??One unit is defined as the amount of enzyme that transfer 1?mol Neu5Ac from CMP-Neu5Ac to lactose to form Sia?2,3Lac per min at 37?C
Package : ? 10 U, 50 U, 250 U
10 in stock
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