Glycobiology is a branch of molecular biology that studies the structure, biosynthesis, and biological functions of carbohydrates (glycans) and their interactions with other molecules in biological systems. It plays a crucial role in understanding the intricate roles that carbohydrates play in various physiological and pathological processes. Here are key aspects of glycobiology:
Glycans and Glycoproteins:
Definition: Glycans are complex carbohydrates composed of sugar molecules linked together. Glycoproteins are proteins with attached glycans.
Function: They are involved in cell signaling, adhesion, immune response, and various cellular recognition processes.
Glycosylation:
Process: Glycosylation is the enzymatic process of attaching glycans to proteins, lipids, or other organic molecules.
Types: N-linked and O-linked glycosylation are common types, occurring in the endoplasmic reticulum and Golgi apparatus.
Cellular Recognition and Signaling:
Role: Glycans on cell surfaces participate in recognition events between cells, facilitating processes such as immune response and embryonic development.
Lectins: Proteins that specifically bind to glycans, called lectins, play a key role in cellular recognition.
Diseases and Glycobiology:
Cancer: Altered glycosylation is associated with cancer progression and metastasis.
Genetic Disorders: Defects in glycan synthesis or processing can lead to genetic disorders known as congenital disorders of glycosylation (CDGs).
Glycomics:
Definition: Glycomics is the systematic study of the entire complement of glycans in a cell or organism.
Techniques: Mass spectrometry, nuclear magnetic resonance (NMR), and chromatography are used for glycomic analysis.
Glycoengineering:
Definition: Glycoengineering involves modifying glycan structures on cells or proteins for specific purposes.
Applications: Used in the development of therapeutic proteins, vaccines, and improving the efficacy of biopharmaceuticals.
Glycan-Binding Proteins:
Lectins: Proteins that recognize and bind to specific glycans, serving as tools for studying glycan structures and functions.
Role: Used in various biological assays and diagnostic applications.
Glycobiology in Drug Development:
Targets: Glycans and glycan-binding proteins are potential targets for drug development.
Therapeutic Strategies: Drugs targeting glycan-related processes are being explored for treating diseases such as cancer and infectious diseases.
Glycoconjugates:
Definition: Molecules formed by the combination of a glycan with a non-carbohydrate entity, such as a protein or lipid.
Biological Significance: Play roles in cellular recognition, signaling, and immune response.
Glycobiology is a dynamic field that continues to reveal the importance of carbohydrates in the complexity of biological systems. Understanding the roles of glycans contributes to advancements in medicine, diagnostics, and biotechnology.
Catalog No.: ? A1SE-3020
E.C. : 3.2.1.111
Product Details: E.coli recombinant 1,3-1,4-alpha-L-fucosidase from Bifidobacterium bifidum.
Unit Definition : ?One unit is defined as the amount of enzyme that catalyzes? the formation of 1 ?mo Gal?1-4GlcNAc from Gal?1-4(Fuc?1-3) GlcNAc minute at 45?,pH 6.0.
Package : ? 1 U, 5 U, 25 U
10 in stock
| Name | α1,3-N-acetylgalactosaminyltransferase;Pm1138 |
| Catalog Number | EN01010 |
| E.C. | 2.4.1.- |
| Product Description | E. coli recombinant α1,3-N-acetylgalactosaminyltransferase from Pasteurella multocida |
| Unit Definition | One unit is defined as the amount of enzyme that catalyzes the formation of 1 µmol GalNAcα1,3-GalNAc from UDP-GalNAc and GalNAc per min at 37 °C. |
10 in stock
Catalog No.: A1GE-1201
E.C. : 2.4.1-
Product Details: Chinese Hamster Ovary cell line, CHO-derived
human Alpha-1,4-N-Acetylglucosaminyltransferase
4/A4GNT protein.
Unit Definition : : Measured by its ability to transfer GlcNAc
from UDP-GlcNAc to galactose.
Package : 20 ug, 100 ug, 1 mg
10 in stock
Catalog No.: ? A1GE-2102
E.C. : 3.1.6.12
Product Details: Chinese Hamster Ovary cell line, CHO-derived humanArylsulfatase B/ARSB protein.
Unit Definition : ? Measured by its ability to hydrolyzethe substrate 4-Nitrocatechol Sulfate (PNCS)under the described conditions.
Package : ? 20 ug, 100 ug, 1 mg
10 in stock
Catalog No.: ? A1GE-2103
E.C. : 3.1.6.1
Product Details: Chinese Hamster Ovary cell line, CHO-derived mouseArylsulfatase G/ARSG protein.
Unit Definition : ? Measured by its ability to hydrolyzethe substrate 4-Nitrocatechol Sulfate (PNCS)under the described conditions.
Package : ? 20 ug, 100 ug, 1 mg
10 in stock
Catalog No.: ? A1SE-4033
E.C. : 2.7.7.4
Product Details: E.coli recombinant ATP-Sulfurylase from Anacystis nidulans.
Unit Definition : ? One unit is defined as the amount of enzyme that catalyzes the formation of 1 umol of APS from ATP per min at 37?C.
Package : ? 100 U, 1 kU
10 in stock
Catalog No.: ? A1SE-2010
E.C. : 4.1.1.35
Product Details: E.coli recombinant UDP-glucuronic acid decarboxylase from Arabidopsis thaliana.
Unit Definition : ??One unit is defined as the amount of enzyme that catalyzes the formation of UDP-xylose from 1 ?mol UDP-GlcA per minute at 37?C.
Package : ? 1 U, 5 U, 25 U
9 in stock
| Name | β1,3-galactosyltransferase; CgtB |
| Catalog Number | EN01009 |
| E.C. | 2.4.1.62 |
| Product Description | E. coli recombinant β1,3-galactosyltransferase from Campylobacter jejuni |
| Unit Definition | One unit is defined as the amount of enzyme that catalyzes the formation of 1 µmol Galβ1,3Gal from Gal and UDP-Gal per min at 37 °C. |
10 in stock
| Name | β1,3-N-acetylgalactosaminyltransferase：LgtD |
| Catalog Number | EN01007 |
| E.C. | 2.4.1.79 |
| Product Description | E. coli recombinant β1,3-N-acetylgalactosami-nyltransferase from Neisseria meningitides |
| Unit Definition | One unit is defined as the amount of enzyme that catalyzes the formation of 1 µmol of GalNAcβ1,3-Gal from UDP-GalNAc and Gal per min at 37 °C. |
10 in stock
| Name | β1,3-N-acetylhexaminyltransferase; LgtA |
| Catalog Number | EN01004 |
| E.C. | 2.4.1.56 |
| Product Description | E. coli recombinant β1,3-N-acetylhexosaminyl-transferase from Neisseria meningitides |
| Unit Definition | One unit is defined as the amount of enzyme that catalyzes the formation of 1 µmol of GlcNAcβ1,3Lac from UDP-GlcNAc and lactose per min at 37 °C. |
10 in stock
| piece | ¥34,000.00 |
| piece | ¥216,000.00 |
| piece | ¥198,000.00 |
10 in stock
Catalog No.: ? A1GE-1101
E.C. : 2.4.1.313
Product Details: Chinese Hamster Ovary cell line, CHO-derived humanB3GALNT2 protein.
Unit Definition : ??Measured by its ability to transferGalNAc from UDP-GalNAc to benzyl-GlcNAc.
Package : ? 20 ug, 100 ug, 1 mg
10 in stock
Catalog No.: ? A1GE-1003
E.C. : 2.4.1-
Product Details: Chinese Hamster Ovary cell line, CHO-derivedhuman B3GalT5 protein.
Unit Definition : ??Measured by its ability to transfergalactose from UDP-galactose to N-Acetyl-alpha -D-glucosamine.
Package : ? 20 ug, 100 ug, 1 mg
10 in stock
Catalog No.: ? A1GE-1602
E.C. : 2.4.1.135
Product Details: Chinese Hamster Ovary cell line, CHO-derived humanbeta-1,3-Glucuronyltransferase 1/B3GAT1 protein.
Unit Definition : ??Measured by its ability to transferGlcA from UDP-GlcA to lactose.
Package : ? 20 ug, 100 ug, 1 mg
10 in stock
Catalog No.: ? A1GE-1202
E.C. : 2.4.1.149
Product Details: Trichoplusia ni, High Five(baculovirus)-derivedhuman Beta-1,3-N-Acetylglucosaminyltransferase 2/B3GNT2 protein.
Unit Definition : ??Measured by its ability to transferGlcNAc from UDP-GlcNAc to N-AcetylD-Lactosamine.
Package : ? 20 ug, 100 ug, 1 mg
10 in stock
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