Explore High Quality Monosaccharides for Advanced Glycochemistry Research

The characterisation of high quality monosaccharides has become a main point of advanced glycochemistry, where the development, synthesis, and functional manipulation of carbohydrates play an important role in both fundamental and applied research in the biosciences. Monosaccharides are the critical molecular platform for all complex glycoconjugates such as glycoproteins, glycolipids, and glycosaminoglycans required for various biological processes, including cell recognition, immune signaling, and pathogenesis. The quality or purity of these building blocks plays an important role in glycosylation reactions in which the exact and selective formation of a glycosidic bond is necessary. In present glycochemistry, high quality monosaccharides are utilised not only in their application in traditional synthetic carbohydrate chemistry but are also essential in chemoenzymatic synthesis, which uses enzymes such as glycosyltransferases and glycosidases to produce highly selective glycan structures under light conditions. This field has recently advanced with the addition of automated glycan assembly, consisting of fully or semi-protected monosaccharide donors that can be selectively activated and coupled in a programmed manner.