GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R <=> GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment(s)
The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).