1, 2-O-Isopropylidene-?-D-glucofuranose, CAS:253328-56-2

1,2-O-Isopropylidene-a-D-glucofuranose
1,2-o-Isopropylidene-?-D-glucofuranose is a potent inhibitor of xylan, which is essential for the growth and development of cancer cells. This compound has been shown to inhibit the activity of several kinases involved in cancer cell proliferation, including protein kinase C and acetylcholine kinase. 1,2-o-Isopropylidene-?-D-glucofuranose exhibits anticancer properties and induces apoptosis in human cancer cells. It is an analog of aprepitant, a drug used to prevent chemotherapy-induced nausea and vomiting in cancer patients. This compound may have potential as a therapeutic agent for the treatment of various types of tumors.CAS Number253328-56-2Product Name1,2-O-Isopropylidene-alpha-D-glucofuranoseIUPAC Name1-(6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diolMolecular FormulaC?H??O?Molecular Weight220.22InChIInChI=1S/C9H16O6/c1-9(2)14-7-5(12)6(4(11)3-10)13-8(7)15-9/h4-8,10-12H,3H2,1-2H3SMILESCC1(OC2C(C(OC2O1)C(CO)O)O)CSynonyms(5?)-1,2-O-(1-Methylethylidene)-?-D-xylo-hexofuranose;CAS No: 18549-40-1,253328-56-2 Synonyms: Acetone-D-glucoseMonoacetone glucoseMAG??MDL No: MFCD00063244 Chemical Formula: C9H16O6 Molecular Weight: 220.22COA:Product name:?1,2-O-Isopropylidene-?-D-glucofuranoseCAS:?18549-40-1,253328-56-2? ? ??M.F.:?C9H16O6? ? ??M.W.:?220.22Quantity:100gfrom1.86 kg? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? Batch No: 20100104ItemsStandardsResultsAppearanceWhite crystal powderCompliesSolubilitySoluble in water, insoluble etherCompliesIdentificationIR and TLCCompliesMelting point150?C?- 160??C156??-158??Optical Activity[?]20/D (C =?1, water)?11?????13?-12.3?WaterMax.0.5%0.2%Residue on ignitionMax. 1%0.1%Heavy metalMax. 20ppmCompliesTLC*Should be one spotOne spotAssayMin. 98%99.4%*The stationary phase is sillica gel, the mobile phase is EtOAc and is?charcoalled with 15% H2SO4-EtOH.
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