3′-Sialyllactose

3′-Sialyllactose

3′-Sialyllactose (CAS No. 35890-38-1) is a complex carbohydrate that plays a significant role in nutrition and health, particularly in relation to human and bovine milk. This trisaccharide consists of galactose, glucose, and N-acetylneuraminic acid (Neu5Ac), making it a vital component of human milk oligosaccharides (HMOs).

Chemical Properties:

• Molecular Formula: C23H39NO19
• Molecular Weight: 633.55 g/mol
• MDL No.: MFCD00168068
• Boiling Point: 1132.8 °C at 760 mmHg
• Flash Point: 638.9 °C
• Density: 1.72 g/cm³
• Solubility: Water-soluble at 20 mg/mL, producing a clear, colorless solution.
• Storage Temperature: Recommended at −20 °C.

3′-Sialyllactose is recognized for its biological significance, particularly in the context of infant nutrition. It serves as a prebiotic that supports gut health by promoting beneficial bacteria and enhancing immune function. Research indicates that it can inhibit the binding of pathogens to cell surfaces, thereby reducing the risk of infections in infants.

In addition to its nutritional benefits, studies have highlighted its potential therapeutic applications, particularly in inflammatory conditions such as rheumatoid arthritis. It has been shown to reduce inflammation and improve immune responses by modulating key signaling pathways like NF-κB.

Citations:

1. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3497896.htm
2. https://pmc.ncbi.nlm.nih.gov/articles/PMC6240131/
3. https://layerorigin.com/blogs/blog-layer-origin-nutrition/what-are-3-sialyllactose-3-sl-and-6-sialyllactose-6-sl
4. https://www.tga.gov.au/resources/resource/compositional-guidelines/3-sialyllactose-sodium
5. https://pubchem.ncbi.nlm.nih.gov/compound/124204218
6. https://www.sigmaaldrich.com/IN/en/product/sigma/a8681
7. https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2020.6098
8. https://hmdb.ca/metabolites/HMDB0000825