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Catalog No: A10GD-4408
Cas No: 37067-30-4
Properties: Mol Formula: C18H21NO8, Mol Weight: 379.4
IUPAC Name: N-[(2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]acetamide
Synonym: 2H-1-Benzopyran-2-one,7-[[2-(acetylamino)-2-deoxy-b-D-glucopyranosyl]oxy]-4-methyl-, MFCD00065481, 4-Methylumbelliferyl-2-acetamido-2-deoxy-|A-D-glucopyranoside
4-Methylumbelliferyl-2-acetamido-2-deoxy-?-D-glucopyranoside is a fluorogenic substrate for ?-hexosaminidases. Upon enzymatic cleavage by ?-hexosaminidases, 4-methylumbelliferone (4-?U) is released and its fluorescence can be used to quantify ?-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-2-acetamido-2-deoxy-?-D-glucopyranoside has been used to quantify ?-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease, which is characterized by defects in the ? subunit of ?-hexosaminidase.
| CAS Number | 37067-30-4 |
| Product Name | 4-Methylumbelliferyl-N-acetyl-beta-D-glucosaminide |
| IUPAC Name | N-[(3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]acetamide |
| Molecular Formula | C18H21NO8 |
| Molecular Weight | 379.4 g/mol |
| InChI | InChI=1S/C18H21NO8/c1-8-5-14(22)26-12-6-10(3-4-11(8)12)25-18-15(19-9(2)21)17(24)16(23)13(7-20)27-18/h3-6,13,15-18,20,23-24H,7H2,1-2H3,(H,19,21)/t13-,15-,16-,17-,18?/m1/s1 |
| InChI Key | QCTHLCFVVACBSA-JVNHZCFISA-N |
| SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)NC(=O)C |
| Synonyms | 4-methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside, 4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, 4-methylumbelliferyl-N-acetyl-beta-D-glucosaminide, 4-methylumbelliferyl-N-acetyl-beta-glucosamine, 4-methylumbelliferyl-N-acetylglucosaminide, 4-MU-Glc-NAc, 4-MUAG, MUABG |
| Canonical SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)NC(=O)C |
| Isomeric SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(=O)C |
CAS No: 37067-30-4 Synonyms: 4-Methylumbelliferyl N-acetyl-b-D-glucosaminide4-MU-GlcNAcGlcNAc-b-4MU MDL No: MFCD00065481 Chemical Formula: C18H21NO8.2H2O Molecular Weight: 415.4 |
White crystal powder. In Stock.?? |
COA:
Product name: 4-Methylumbelliferyl N-acetyl-?-D-glucosaminide dihydrate
CAS: 37067-30-4 M.F.: C18H21NO8.2H2O M.W.: 415.4
|
Items |
Standards |
Results |
|
Appearance |
White crystal powder |
Complies |
|
Solubility |
Soluble in DMF, insoluble ether |
Complies |
|
Identification |
IR and HPLC |
Complies |
|
NMR and MS |
Should comply |
Complies |
|
Melting point |
208? ~ 215 ?C |
208? ~210? |
|
Heavy metal |
Max. 20ppm |
Complies |
|
Residue on ignition |
Max. 0.5% |
0.1% |
|
Water Content ?K.F.? |
Max. 2% |
0.9% |
|
4-Methylumbelliferone |
Max. 0.1% |
Complies |
|
TLC |
Should be one spot |
One spot |
|
Assay by HPLC |
Min. 98% |
99.2% |
References:
1. Leaback DH, Walker PG, Biochem. J. 1961, 78, p151
| Size | 1 G, 100 MG, 5 G, Other |
|---|
IUPAC:Gal(b1-3)GlcNAc(b1-3)Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc, G62097SF
10 in stock
Gal-a1,3-(Fuc-a1,2)-Gal-b1,4-Glc, CAS:59957-92-5, G06873PC
10 in stock
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