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Catalog No: A10GD-4136
Cas No: 460085-45-4
Properties: Mol Formula: C16H18NNaO10S, Mol Weight: 439.4
IUPAC Name: sodium;N-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]sulfamate
Synonym: 4-MU-|A-GlcNS (sodium), 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-alpha-D-glucopyranoside Sodium Salt, sodium
4-Methylumbelliferyl N-sulpho-a-D-glucosaminide.Na; 4-MU-GlcNS; M3A; 4MU-a-N-sulpho-D-glucosaminide
A substrate used for the diagnosis of Sanfilippo disease type A (MPS IIIA).
4-Methylumbelliferyl 2-sulfamino-2-deoxy-?-D-Glucopyranoside (4-MU-?-GlcNS) is a fluorogenic substrate of heparin sulphamidase. Heparin sulphamidase cleaves 4-MU-?-GlcNS to yield 4-MU-?-GlcNH2, which is then cleaved by ?-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm. The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. 4-MU-?-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.
| CAS Number | 460085-45-4 |
| Product Name | 4-Methylumbelliferyl 2-deoxy-2-sulfamino-alpha-D-glucopyranoside sodium salt |
| IUPAC Name | sodium;N-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]sulfamate |
| Molecular Formula | C??H??NNaO??S |
| Molecular Weight | 439.37 |
| InChI | InChI=1S/C16H19NO10S.Na/c1-7-4-12(19)26-10-5-8(2-3-9(7)10)25-16-13(17-28(22,23)24)15(21)14(20)11(6-18)27-16;/h2-5,11,13-18,20-21H,6H2,1H3,(H,22,23,24);/q;+1/p-1/t11-,13-,14-,15-,16+;/m1./s1 |
| SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)NS(=O)(=O)[O-].[Na+] |
| Synonyms | 7-[[2-Deoxy-2-(sulfoamino)-?-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one Sodium Salt; |
| Size | 1 G, 100 MG, 5 G, Other |
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10 in stock
Gal-a1,3-(Fuc-a1,2)-Gal-b1,4-Glc, CAS:59957-92-5, G06873PC
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IUPAC:Fuc(a1-2)[Gal(a1-3)]Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)b-Glc, G63238VS
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