D-Mannitol, CAS:69-65-8

D-MannitolTitle: MannitolCAS Registry Number: 69-65-8Additional Names: D-Mannitol; mannite; manna sugar; cordycepic acidTrademarks: Manicol; Mannidex; Osmitrol (Baxter); Osmosal; Resectisol (McGaw)Molecular Formula: C6H14O6Molecular Weight: 182.17Percent Composition: C 39.56%, H 7.75%, O 52.70%Literature References: Widespread in plants and plant exudates; obtained from manna and seaweeds: The Carbohydrates, W. Pigman, Ed. (Academic Press, New York, 1957) pp 249-250. Forms a stable, equimolar compound with H2O2: S. Tanatar, J. Russ. Phys. Chem. Soc. 40, 376, C.A. 3, 883 (1909). Prepd by electrolytic reduction of glucose: Creighton, Can. Chem. Process Ind. 26, 690 (1942), C.A. 37, 10885 (1943); Wolfrom et al., J. Am. Chem. Soc. 68, 578 (1946). Prepn from seaweed: Sorensen, Kristensen, US 2516350 (1950); by hydrogenation of invert sugar, monosaccharides, and sucrose: Kasehagen, and Kasehagen, Luskin, US 2642462, US 2749371, and US 2759024 (1953, 1956, and 1956, all to Atlas Powder). Review of prepn: Pigman, loc. cit. Novel synthesis: M. Makkee et al., Chem. Commun. 1980, 930.Properties: Orthorhombic needles from alc, mp 166-168?. Sweetish taste. d20 1.52. bp3.5 290-295?. Is inactive or very slightly levorotatory in distilled water. Forms sodium mannitoborate on addition of borax giving a greater rotation: [a]D20 +23? ? +24? after 1 hr in a soln of 10 g mannitol +12.8 g borax + sufficient H2O to make 100 ml. One gram dissolves in ~5.5 ml water, 83 ml alcohol; more sol in hot water. Insol in ether. Sol in pyridine, aniline, aq solns of alkalies. One gram dissolves in 18 ml glycerol (d 1.24). Soly tables: Creighton, Klauder, J. Franklin Inst. 195, 687 (1923). pKa (18?): 13.50.Melting point: mp 166-168?Boiling point: bp3.5 290-295?pKa: pKa (18?): 13.50Optical Rotation: [a]D20 +23? ? +24? after 1 hr in a soln of 10 g mannitol +12.8 g borax + sufficient H2O to make 100 mlDensity: d20 1.52; d 1.24Use: Used with boric acid in the manuf of dry electrolytic condensers for radio applications; in making artificial resins and plasticizers; in pharmacy as excipient and diluent for solids and liqs; in analytical chemistry for boron determinations; in the manuf of mannitol hexanitrate. Used in the food industry as anticaking and free-flow agent, flavoring agent, lubricant and release agent, stabilizer and thickener and nutritive sweetener.Therap-Cat: Diuretic. Diagnostic aid (renal function).Keywords: Diagnostic Aid; Diuretic.CAS Number69-65-8Product NameMannitolIUPAC Name(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexolMolecular FormulaC6H14O6Molecular Weight182.17 g/molInChIInChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1InChI KeyFBPFZTCFMRRESA-KVTDHHQDSA-NSMILESC(C(C(C(C(CO)O)O)O)O)OSolubilitygreater than or equal to 100 mg/mL at 68? F (NTP, 1992)
216000 mg/L (at 25 ?C)
1 g in about 5.5 ml water; more sol in hot water; insol in ether; sol in pyridine, aniline; sol in aq soln of alkalies; 1 g dissolves in 18 ml glycerol (density 1.24); 1 g dissolves in about 83 ml alc
In water, 2.16X10+5 mg/l @ 25 ?C
216 mg/mL at 25 ?CSynonyms(L)-Mannitol, Mannitol, Osmitrol, OsmofundinCanonical SMILESC(C(C(C(C(CO)O)O)O)O)OIsomeric SMILESC([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)OName:?D-Mannitol? ?CAS:?69-65-8? ? ? ? ? ? ??M.F.:?C6H14O6
M.W.:?182.17? ? ? ? ?Batch No:?20120403?Quantity:262gItemsStandardsResultsAppearanceWhite crystalline powerPositiveSolubilityReadily soluble in water andinsoluble in etherPositiveNMR and MSShould complyCompliesIdentificationIR and TLCPositiveM.P.160??~170?162??~165?Loss Weight On DrynessMax. 1%CompliesHeavy MetalMax. 20ppmCompliesTLC?(15%H2SO4-C2H5OH)One spotCompliesAssay (HPLC)Min. 98%99.6%