GDP-ManA

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CAS: N/A

MW: 685.27

Purity: ≥96%

Chemical Formula: C16H20N5Na3O17P2

Synonym: Guanosine 5′-diphospho-D-mannuronic acid trisodium salt

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Description

Guanosine 5′-diphospho-D-mannuronic acid trisodium salt is a nucleotide sugar. It is involved in the biosynthesis of various polysaccharides and glycoconjugates in certain organisms, primarily in bacterial and plant cell wall biosynthesis. GDP-mannuronic acid is often used in studies of polysaccharide synthesis, particularly alginate biosynthesis in bacteria like Pseudomonas and Azotobacter.

Structure & Properties:

  • Molecular Weight (MW): Typically around 600-650 g/mol (depending on the exact salt form).
  • Chemical Formula: C16H21N5Na3O18P2 (estimate based on similar compounds, but may vary slightly depending on hydration state)
  • Synonyms: GDP-Mannuronic acid trisodium salt, Guanosine diphospho-D-mannuronic acid trisodium salt
  • CAS Number: Not widely available for this specific compound, but similar GDP-sugar analogs are often used in research contexts.

Biological Role:

  • Biosynthesis: This compound serves as a sugar donor in glycosylation reactions, particularly in the synthesis of polysaccharides like alginate in bacteria. Alginate is a key structural component of biofilms and is important in bacterial virulence and defense.
  • Function: It acts as a substrate for glycosyltransferase enzymes that catalyze the transfer of mannuronic acid residues during the biosynthesis of polysaccharides like alginate. In plants, GDP-sugars are involved in the synthesis of hemicelluloses and pectins.

Applications:

  1. Polysaccharide Biosynthesis Studies: Used to study the formation of bacterial extracellular polysaccharides such as alginate, which are important for biofilm formation and bacterial pathogenesis.
  2. Enzyme Assays: It is often used in assays to study glycosyltransferases involved in alginate and other polysaccharide synthesis pathways.
  3. Biofilm Research: Essential in understanding biofilm-related infections and developing treatments targeting biofilm formation.
  4. Glycobiology Research: It is important in the study of glycan synthesis and modifications.

Storage and Stability:

  • Storage: Typically stored at -20°C in a dry, sealed container to protect it from moisture and degradation.
  • Stability: Stable under recommended storage conditions, but sensitive to moisture and should be handled with care.

Significance in Research:

  • Bacterial Research: Its role in alginate biosynthesis makes it significant in studies related to bacterial pathogenicity, particularly in diseases like cystic fibrosis where Pseudomonas aeruginosa biofilms are a major concern.
  • Material Science: Alginate, derived from this compound, has applications in drug delivery systems, wound healing, and as a food additive.

This compound is particularly valuable in microbiology and glycoscience research, providing insights into polysaccharide biosynthesis and its implications for health and disease.

Product Documents

2. MSDS

3. Tech Data Sheets/Manuals

Additional information

Size

15 MG, 25 MG, 5 MG

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