DiLacNAc(Galb1, 4GlcNAcb1, 3Galb1, 4GlcNAc)

DiLacNAc (Galβ1-4GlcNAcβ1-3Galβ1-4GlcNAc)

Product Description

DiLacNAc is a structurally defined tetrasaccharide glycan composed of two repeating N-acetyllactosamine (LacNAc) units, represented as Galβ1-4GlcNAcβ1-3Galβ1-4GlcNAc. The molecule contains alternating β-linked galactose (Gal) and N-acetylglucosamine (GlcNAc) residues, forming a characteristic LacNAc repeat motif commonly found in complex glycans of glycoproteins and glycolipids.

N-acetyllactosamine repeats are fundamental structural components of many N-linked and O-linked glycans present on mammalian cell surfaces. These glycan motifs play critical roles in cell recognition, immune regulation, pathogen interaction, and carbohydrate-mediated signaling pathways. Because of its defined structure and biological relevance, DiLacNAc serves as an important reagent for glycobiology research and glycan engineering studies.

DiLacNAc is widely used as a model glycan for studying carbohydrate-protein interactions, particularly in investigations involving lectins, antibodies, and glycan-binding proteins. It also serves as a synthetic intermediate and building block for the preparation of more complex glycans and glycoconjugates used in biological and pharmaceutical research.

Structural Information

The molecule consists of two repeating LacNAc units, which are disaccharides formed by galactose linked to N-acetylglucosamine via a β1-4 glycosidic bond. These repeating units are connected through a β1-3 linkage, creating the tetrasaccharide structure.

Such LacNAc repeating sequences are important components of poly-N-acetyllactosamine chains, which are frequently involved in biological processes such as cell adhesion, immune recognition, and glycan-mediated cell signaling.

Key Features

• Defined tetrasaccharide glycan containing two LacNAc repeats
• Alternating β-linked galactose and N-acetylglucosamine residues
• Suitable for advanced glycobiology and carbohydrate research
• Useful as a glycan building block for complex oligosaccharide synthesis
• Available in flexible quantities from milligrams to kilograms

Applications

Glycobiology Research

DiLacNAc is frequently used as a model compound for studying the biological roles of LacNAc motifs in glycoproteins and glycolipids, particularly in cell surface glycan interactions.

Lectin Binding and Glycan Recognition Studies

Many lectins and glycan-binding proteins recognize LacNAc motifs. DiLacNAc can be used to investigate carbohydrate recognition mechanisms and binding specificity.

Glycan Synthesis and Glycoengineering

This compound serves as an important intermediate for synthesizing larger oligosaccharides, glycoproteins, and glycoconjugates, making it valuable for glycoengineering and synthetic carbohydrate chemistry.

Enzyme Activity Studies

DiLacNAc can be used as a substrate or model compound in studies involving glycosyltransferases and glycosidases, enzymes that participate in glycan biosynthesis and degradation.Immunology and Cell Signaling Research

LacNAc-containing glycans are known to participate in immune modulation, cell adhesion, and signaling pathways, making DiLacNAc a useful molecule in biomedical research.

Physical Appearance

Typically supplied as a white to off-white powder suitable for biochemical and analytical applications.

Storage Conditions

• Store at −20 °C for long-term stability
• Keep the container tightly sealed and protected from moisture
• Avoid repeated freeze-thaw cycles

Packaging Options

DiLacNAc is available in flexible packaging sizes ranging from milligram quantities for research laboratories to kilogram-scale production for industrial and large-scale applications.