Glucoraphanin Potassium Salt

Glucoraphanin Potassium Salt

Glucoraphanin potassium salt is a potassium salt form of glucoraphanin, a naturally occurring glucosinolate predominantly found in cruciferous vegetables such as broccoli, Brussels sprouts, and kale. This compound is of significant interest due to its potential health benefits and role in plant defense mechanisms.

Chemical Identity

• CAS Number: 1453081-26-9
• Alternate CAS Number: 21414-41-5 (non-salt form)
• IUPAC Name: Potassium (R)-4-methylsulfinylbutyl 2-(β-D-glucopyranosyloxy)acetate
• Molecular Formula: C₁₂H₂₂KNO₁₀S₃
• Molecular Weight: 475.6 g/mol

Physical Properties

• Appearance: White to off-white solid
• Purity: ≥97% (commonly confirmed via HPLC)
• Solubility: Soluble in water and polar organic solvents; hygroscopic in nature.
• Stability: Stable under normal laboratory conditions but should be stored in a cool, dry place to maintain integrity.

Structural Features

Glucoraphanin potassium salt consists of:

• A D-glucopyranose moiety linked to a 4-methylsulfinylbutyl side chain, which is characteristic of glucosinolates.
• The potassium salt form enhances solubility and bioavailability compared to its non-salt counterpart.

Biological Significance

• Metabolism: Upon hydrolysis by the enzyme myrosinase, glucoraphanin is converted into sulforaphane, a compound known for its potential chemopreventive properties and ability to induce phase II detoxification enzymes.
• Health Benefits: Research suggests that sulforaphane may have anticancer effects, support cardiovascular health, and provide neuroprotective benefits. Glucoraphanin itself is studied for its role in modulating hepatic cytochrome P450 enzymes and phase II conjugation activities.

Applications

Glucoraphanin potassium salt is utilized in various fields:

• Nutraceuticals: Incorporated into dietary supplements aimed at enhancing health through the consumption of cruciferous vegetables.
• Research: Used in studies investigating the metabolic pathways of glucosinolates and their effects on human health.
• Plant Biology: Investigated for its role in plant defense mechanisms against pests and diseases.

Safety and Handling

• Hazard Statements: Generally regarded as safe when handled properly; however, standard laboratory precautions should be observed.
• Storage Conditions: Store at -20°C in a tightly sealed container to prevent moisture absorption.

Regulatory Information

This compound is expected to comply with TSCA regulations for research use only (RUO). It should be verified for specific handling requirements based on local regulations.

Glucoraphanin potassium salt is commercially available for research purposes and serves as an important compound in the study of plant biology and potential health benefits associated with cruciferous vegetables.

Citations:

1. https://www.scbt.com/p/r-glucoraphanin-potassium-salt-21414-41-5-non-salt-
2. https://www.enzo.com/product/r-glucoraphanin-potassium-salt/
3. https://cymitquimica.com/products/TR-G450255/21414-41-5/glucoraphanin-potassium-salt-contains-up-to-15-inorganics/
4. https://www.phenomenex.com/-/jssmedia/phxjss/data/media/documents/ImportedFromLegacy/PDFDocuments/TN14810713_W.pdf?rev=a084ad0c9b45414fa19f23fb1edc7d65
5. https://en.wikipedia.org/wiki/Glucoraphanin
6. https://pubchem.ncbi.nlm.nih.gov/compound/R-_-_-Glucoraphanin-potassium-salt
7. https://syninnova.com/catalog/product/SL-1507
8. https://www.biomol.com/products/chemicals/biochemicals/glucoraphanin-potassium-salt-lkt-g4781.1