Glutaryl-Gly-Arg-AMC.HCl

Glutaryl-glycyl-L-arginine 7-amido-4-methylcoumarin hydrochloride

Glutaryl-glycyl-L-arginine 7-amido-4-methylcoumarin hydrochloride is a potent elastase inhibitor. It has been shown to inhibit the proteolytic activity of elastases and serine proteinases, which are responsible for lysosomal degradation. This drug has also been shown to have strong anti-infective properties against tropical diseases such as leishmaniasis, malaria, and schistosomiasis. Glutaryl-glycyl-L-arginine 7-amido-4-methylcoumarin hydrochloride is also effective against human skin diseases such as psoriasis and atopic dermatitis. The mechanism of action of this drug may be due to its ability to inhibit the production of metalloproteinases that degrade collagen in the extracellular matrix (ECM), leading to a reduction in ECM degradation and an increase in ECM synthesis.