Lacto-N-tetraose (LNT)

Lacto-N-tetraose (LNT) – Type 1 Chain HMO Product Overview Lacto-N-tetraose (LNT) is a naturally occurring human milk oligosaccharide (HMO) belonging to the lacto-series type-1 chain glycans. It is composed of four monosaccharide units — galactose (Gal), N-acetylglucosamine (GlcNAc), galactose (Gal), and glucose (Glc) — arranged in the linkage Galβ1-3GlcNAcβ1-3Galβ1-4Glc. LNT is one of the most abundant neutral oligosaccharides in human breast milk and serves as a biologically active soluble glycan. It plays a significant role in shaping the infant gut microbiota and in mediating host–microbe interactions. Due to its well-defined structure, LNT is widely used as a model compound in studies involving microbiome modulation, pathogen adhesion inhibition, and carbohydrate recognition . Applications Human milk oligosaccharide (HMO) and infant nutrition research Microbiome and probiotic growth studies (e.g., Bifidobacteria utilization) Pathogen binding and anti-adhesion assays Glycan-protein and lectin interaction analysis Analytical reference standard for HPLC, LC-MS, and NMR Glycosyltransferase and enzymatic synthesis studies Development of glycan microarrays and carbohydrate libraries Key Features Naturally occurring HMO (type-1 chain) Structurally defined neutral oligosaccharide Biologically relevant for host–microbiota interaction studies High purity and reproducible performance Suitable for biochemical and analytical assays Storage & Handling Store at −20 °C in a dry, sealed container Protect from moisture and repeated freeze-thaw cycles Bring vial to room temperature before opening