Rebaudioside A

Rebaudioside A

Rebaudioside A (CAS No. 58543-16-1) is a steviol glycoside derived from the leaves of Stevia rebaudiana, known for its intense sweetness and stability. It is commonly used as a natural sweetener in various food and beverage products.

Chemical and Physical Properties

• CAS Number: 58543-16-1
• MDL Number: MFCD02183463
• Molecular Formula: C₄₄H₇₀O₂₃
• Molecular Weight: 967.01 g/mol
• Boiling Point: 1103.5°C at 760 mmHg
• Melting Point: 235°C (lit.)
• Density: 1.58 g/cm³
• Appearance: Off-white powder
• Optical Rotation: -33.0 ± 3.0° (c=1% in H₂O)
• Storage: Store at 2–8°C for long-term stability (months).

Structure and Composition

Rebaudioside A is composed of multiple glucose units linked to a steviol backbone, contributing to its sweetness—approximately 240 times sweeter than sucrose. The structure includes four glucose molecules, with specific glycosidic linkages that enhance its sweetness while minimizing bitterness compared to other steviol glycosides like stevioside.

Biological Activity and Applications

Rebaudioside A is widely recognized for its use as a natural sweetener in food and beverages due to its favorable taste profile and low caloric content. It has been approved for use in many countries and is considered safe for consumption. Its applications include:

• Food Industry: Used in beverages, baked goods, dairy products, and confections as a sugar substitute.
• Health Benefits: Potential antioxidant properties and minimal impact on blood glucose levels make it suitable for diabetics.

Safety and Regulatory Status

Rebaudioside A has been evaluated for safety by various health authorities, including the FDA, which recognizes it as Generally Recognized As Safe (GRAS). Studies indicate that it does not exhibit genotoxicity or significant adverse effects when consumed within recommended limits.

Storage Recommendations

To maintain its stability and quality, Rebaudioside A should be stored in a cool, dry place at temperatures between 2–8°C.

In summary, Rebaudioside A is a prominent natural sweetener with excellent stability and sweetness profile, making it a popular choice in the food industry for those seeking healthier alternatives to sugar.

Citations:

1. https://pubchem.ncbi.nlm.nih.gov/compound/Rebaudioside-A
2. https://www.fda.gov/files/food/published/GRAS-Notice-000632–Rebaudioside-A-from-%3Ci%3EYarrowia-lipolytica%3C-i%3E.pdf
3. https://en.wikipedia.org/wiki/Rebaudioside_A
4. https://www.biochemjournal.com/archives/2024/vol8issue11/PartC/8-10-173-459.pdf
5. https://www.sigmaaldrich.com/IN/en/product/sial/phr2697
6. https://standards.chromadex.com/REBAUDIOSIDE-A