STN Epitope; 6-O-a-Sialyl-2-acetamido-2-deoxy-a-D-galactopyranosyl-1-O-serine

STN Epitope; 6-O-a-Sialyl-2-acetamido-2-deoxy-a-D-galactopyranosyl-1-O-serine ;2-Acetamido-6-O-(a-2-N-acetylneuraminyl)-2-deoxy-a-D-galactopyranosyl serine2-Acetamido-6-O-(a-2-N-acetylneuraminyl)-2-deoxy-a-D-galactopyranosyl serine is a monosaccharide sugar that is the terminal sugar at the nonreducing end of the glycosidic linkage in gangliosides. It has been shown to be a marker for colorectal adenocarcinoma and may be used as a prognostic marker. 2-Acetamido-6-O-(a-2-N-acetylneuraminyl)-2-deoxy–aDgalactopyranosyl serine, along with other gangliosides, has been found to be elevated in maternal blood and human serum during bowel diseases such as ulcerative colitis. This molecule has also been shown to have structural similarities to antigens that are associated with infectious diseases such as malaria.
CAS Number114661-01-7Product NameSTn EpitopeIUPAC Name5-acetamido-2-[[5-acetamido-6-(2-amino-2-carboxyethoxy)-3,4-dihydroxyoxan-2-yl]methoxy]-4-hydroxy-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acidMolecular FormulaC??H??N?O??Molecular Weight599.5 g/molInChIInChI=1S/C22H37N3O16/c1-7(27)24-13-10(29)3-22(21(36)37,41-18(13)15(31)11(30)4-26)39-6-12-16(32)17(33)14(25-8(2)28)20(40-12)38-5-9(23)19(34)35/h9-18,20,26,29-33H,3-6,23H2,1-2H3,(H,24,27)(H,25,28)(H,34,35)(H,36,37)InChI KeyRMINQIRDFIBNLE-NNRWGFCXSA-NSMILESCC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)OCC2C(C(C(C(O2)OCC(C(=O)O)N)NC(=O)C)O)O)OSynonymsSerinyl 2-Acetamido-2-deoxy-6-O-(?-2-N-Acetylnuraminyl)-?-D-galactopyranosyl; 6-O-?-Sialyl-2-acetamido-2-deoxy-?-D-galactopyranosyl-1-O-L-serine; O-[2-(acetylamino)-6-O-(N-acetyl-?-neuraminosyl)-2-deoxy-?-D-galactopyranosyl]-L-serine;Canonical SMILESCC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)OCC2C(C(C(C(O2)OCC(C(=O)O)N)NC(=O)C)O)O)OIsomeric SMILESCC(=O)N[C@@H]1[C@H](C[C@@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)O)OC[C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)OC[C@@H](C(=O)O)N)NC(=O)C)O)O)O