Tinnevellin glucoside

Tinnevellin glucoside

Tinnevellin glucoside, with the CAS number 80358-06-1, is a naturally occurring naphthalene glycoside derived from the leaves and pods of the Cassia angustifolia plant, commonly known as Alexandrian senna. This compound has garnered attention due to its potential biological activities and applications in herbal medicine.

Chemical Identity

• CAS Number: 80358-06-1
• MDL Number: MFCD28964208
• Molecular Formula: C20H24O9
• Molecular Weight: 408.40 g/mol
• EINECS Number: Not specified

Physical and Chemical Properties

1. Appearance: Tinnevellin glucoside typically appears as a white to light yellow powder.
2. Solubility: It is soluble in water and various organic solvents, making it suitable for different extraction and formulation processes.
3. Stability: The compound is stable under standard laboratory conditions, although it should be stored in a cool, dry place to maintain its integrity.

Biological Activities

Tinnevellin glucoside exhibits several noteworthy biological properties:

1. Antioxidant Activity: Research indicates that it can reduce oxidative stress in cells by scavenging free radicals, which may contribute to cellular protection.
2. Antimicrobial Properties: Tinnevellin glucoside has shown activity against various pathogens, suggesting potential applications in combating infections.
3. Glucose Uptake Enhancement: Studies have demonstrated that it enhances GLUT4 translocation in muscle cells, which may improve glucose uptake and metabolism.
4. Laxative Effects: As a component of herbal formulations, it is known for its laxative properties, stimulating bowel movements by enhancing intestinal motility and increasing water content in the intestines.

Applications

Tinnevellin glucoside has several applications in both research and industry:

1. Quality Control in Herbal Medicine: It serves as a marker for the authentication of senna species in herbal preparations, ensuring the quality and efficacy of herbal medicines.
2. Pharmaceutical Research: Its biological activities make it a candidate for further investigation in drug development, particularly concerning its antioxidant and antimicrobial effects.
3. Traditional Medicine: Historically used in traditional medicine systems for its laxative properties, it remains popular in herbal formulations aimed at digestive health.

Synthesis and Extraction

Tinnevellin glucoside can be extracted from Cassia angustifolia through various methods, including hydroalcoholic extraction followed by purification techniques such as liquid chromatography. Synthetic routes may involve chemical reactions that modify naphthalene derivatives to produce the glycosidic structure characteristic of Tinnevellin glucoside.

Safety Information

While Tinnevellin glucoside is generally regarded as safe for use in herbal formulations, standard safety practices should be followed:

• Use personal protective equipment (PPE) when handling the compound.
• In case of contact with skin or eyes, rinse thoroughly with water.
• Store in a cool, dry place away from direct sunlight.

Citations:

1. https://pubchem.ncbi.nlm.nih.gov/compound/Tinnevellin-glucoside
2. https://www.benchchem.com/zh/product/b192543
3. https://www.phytopurify.com/Tinnevellinglucoside-p-5639.html
4. https://www.sigmaaldrich.com/IN/en/product/supelco/phl83917
5. https://phyproof.phytolab.com/en/reference-substances/details/tinnevellin-glucoside-83917
6. https://www.glentham.com/en/products/product/GY2419/
7. https://www.biosynth.com/p/FT145279/80358-06-1-tinnevellin-glucoside
8. https://karger.com/pha/article-pdf/47/Suppl.%201/2/3416252/000139654.pdf