Triacetyl-β-cyclodextrin

Triacetyl-β-cyclodextrin

Triacetyl-β-cyclodextrin (CAS No. 23739-88-0) is a modified derivative of β-cyclodextrin, characterized by the acetylation of its hydroxyl groups. This compound is widely recognized for its applications in pharmaceuticals, food science, and various industrial processes due to its ability to form inclusion complexes and enhance solubility.

Chemical Identification

• CAS Registry Number: 23739-88-0
• MDL Number: MFCD29127435
• EINECS: Not specified
• Molecular Formula: C84H112O56
• Molecular Weight: 2,017.75 g/mol
• IUPAC Name: Triacetyl-β-cyclodextrin
• Synonyms: Acetylated β-cyclodextrin

Physical Properties

Chemical Properties

Triacetyl-β-cyclodextrin is a water-insoluble compound that exhibits excellent solubilizing properties for hydrophobic compounds. It can form stable inclusion complexes with various guest molecules, enhancing their solubility and bioavailability.

Applications

1. Pharmaceuticals:
   • Used as a drug carrier for controlled release formulations, improving the solubility and stability of poorly soluble drugs.
   • Acts as an excipient in tablet formulations and injectable preparations.
2. Food Industry:
   • Functions as an emulsifier and stabilizer, enhancing the texture and shelf-life of food products.
   • Employed in the encapsulation of flavors and nutrients to improve their stability.
3. Biotechnology:
   • Utilized in the extraction of aromatic amino acids and other compounds due to its ability to form inclusion complexes.
   • Serves as a polymerization initiator for cyclic esters.
4. Cosmetics:
   • Incorporated into cosmetic formulations for improved texture and stability.

Safety and Handling

• Hazards: Generally regarded as safe; however, appropriate handling precautions should be taken to avoid inhalation or skin contact.
• Precautions: Use personal protective equipment (PPE) such as gloves and goggles when handling the material. Store in a cool, dry place away from incompatible substances.

Key Notes

• Purity: Available at 97% purity (Catalog No. A878154).
• The compound’s unique properties make it suitable for diverse applications across multiple industries.
• Regulatory status includes listings in chemical databases for research use.

Triacetyl-β-cyclodextrin’s ability to enhance solubility and stabilize active ingredients makes it a valuable compound in both scientific research and commercial applications.

Citations:

1. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB5336407.htm
2. https://pmc.ncbi.nlm.nih.gov/articles/PMC11050477/
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC3225529/
4. https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00090/full
5. https://www.tandfonline.com/doi/full/10.3109/10717544.2014.938839
6. https://www.tcichemicals.com/IN/en/p/T1844
7. https://www.mdpi.com/2073-4360/14/1/104
8. https://www.sigmaaldrich.com/IN/en/product/aldrich/332623