Vitexin 4′-Glucoside

Vitexin 4′-Glucoside

Vitexin 4′-glucoside is a flavonoid glycoside that has garnered attention for its potential health benefits and biological activities. Below is a comprehensive overview of its properties, applications, and safety information.

Chemical Properties

• CAS Number: 38950-94-6
• MDL Number: Not specified
• Catalog Number: A1202985
• Molecular Formula: C27H30O15
• Molecular Weight: 594.52 g/mol
• Boiling Point: 937.3 ± 65.0 °C (predicted)
• Melting Point: 230 °C
• Density: Approximately 1.81 g/cm³ (predicted)
• Solubility:
  • Soluble in DMSO and DMF.
  • Slightly soluble in PBS (pH 7.2).

Structural Information

Vitexin 4′-glucoside consists of a vitexin core structure with a glucosyl group attached at the 4′ position. This structural modification enhances its solubility and bioactivity. The compound can be represented by the following SMILES notation:

OC1=CC(O)=C(C(C=C(C2=CC=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2)O4)=O)C4=C1[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO\text{OC1=CC(O)=C(C(C=C(C2=CC=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2)O4)=O)C4=C1[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO}OC1=CC(O)=C(C(C=C(C2=CC=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2)O4)=O)C4=C1[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO

Biological Activities

Vitexin 4′-glucoside exhibits several biological properties, including:

1. Antioxidant Activity: It helps in scavenging free radicals, thereby reducing oxidative stress in cells.
2. Anti-inflammatory Effects: The compound has shown potential in modulating inflammatory pathways, making it beneficial in inflammatory conditions.
3. Neuroprotective Properties: Research indicates that it may protect neuronal cells from damage, which is significant for neurodegenerative disease research.
4. Cardiovascular Benefits: It may contribute to cardiovascular health by improving endothelial function and reducing blood pressure.

Applications

Vitexin 4′-glucoside is utilized in various fields:

• Pharmaceutical Research: Investigated for its potential therapeutic effects in treating cardiovascular diseases and neurodegenerative disorders.
• Nutraceuticals: Incorporated into dietary supplements for its health-promoting properties.
• Biochemical Studies: Used to explore the mechanisms of flavonoids and their interactions within biological systems.

Safety Information

While specific hazard classifications may not be detailed, general safety precautions should be observed:

1. Storage Conditions: Store at -20 °C to maintain stability; avoid repeated freeze-thaw cycles.
2. Handling Precautions: Use appropriate personal protective equipment (PPE), such as gloves and goggles, to prevent exposure.
3. First Aid Measures:
   • Inhalation: Move to fresh air; seek medical attention if symptoms occur.
   • Skin Contact: Wash thoroughly with soap and water; consult a physician if irritation persists.
   • Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical help if irritation develops.
   • Ingestion: Do not induce vomiting; rinse mouth and seek immediate medical assistance.

Synonyms

The compound is known by several alternative names, including:

• Vitexin 4′-O-glucoside
• 4′-O-glucosylvitexin
• Vitexin-4”-O-glucoside

This detailed description highlights the significance of Vitexin 4′-glucoside in scientific research and potential therapeutic applications, emphasizing its chemical properties, biological activities, applications, and safety considerations.

Citations:

1. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB82743239.htm
2. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3119208.htm
3. https://pubchem.ncbi.nlm.nih.gov/compound/Vitexin-4_-O-glucoside
4. https://www.glpbio.com/sp/gc37915.html
5. https://www.medchemexpress.com/vitexin-4-glucoside.html
6. https://www.sigmaaldrich.com/IN/en/product/sigma/smb01021
7. https://file.medchemexpress.com/batch_PDF/HY-N4085/Vitexin-4-glucoside-COA-231297-MedChemExpress.pdf
8. https://en.wikipedia.org/wiki/Vitexin