Activated sugar nucleotide donor substrate for mannosyltransferases; essential for N-linked glycoprotein biosynthesis, GPI-anchor assembly, and ascorbic acid (vitamin C) biosynthesis in plants
Azido-modified analogue of UDP-GlcNAc; serves as a substrate for O-GlcNAc transferase (OGT) and N-acetylglucosaminyltransferases enabling metabolic and chemoenzymatic glycan labeling; the azidoacetyl handle permits bioorthogonal conjugation via copper-catalyzed azide–alkyne cycloaddition (CuAAC) and strain-promoted azide–alkyne cycloaddition (SPAAC); can be epimerized to UDP-GalNAz by UDP-galactose-4-epimerase (GALE); widely used in O-GlcNAc proteomics, glycan imaging, and selective probing of intracellular O-GlcNAcylation
Cytidine-5’-monophospho-N-glycolylneuraminic acid, Disodium Salt
Synonyms
CMP-Neu5Gc·2Na, CMP-NeuGc Disodium Salt, CMP-N-Glycolylneuraminic Acid Disodium Salt
Molecular Formula
C20H29N4O17P · 2Na
Molecular Weight
674.41 g/mol
CAS No.
98396-76-0
Appearance
White lyophilized powder
Purity
≥95% (HPLC)
Source
Enzymatic synthesis
Solubility
Soluble in water
Storage
−20°C, protect from moisture
Application
Activated sugar nucleotide donor substrate for sialyltransferases; used in enzymatic glycolyl-sialylation of glycoproteins, glycolipids, and oligosaccharides; key tool for studying non-human Neu5Gc expression and anti-Neu5Gc immune responses