γ-Cyclodextrin hydrate

γ-Cyclodextrin hydrate

γ-Cyclodextrin hydrate (CAS No. 91464-90-3) is a cyclic oligosaccharide composed of eight glucose units linked by α-1,4-glycosidic bonds. Its molecular formula is C₄₈H₈₂O₄₁, with a molecular weight of approximately 1315.14 g/mol. The compound appears as a white powder and has a melting point of 267 °C.

Chemical Properties and Structure

• Molecular Formula: C₄₈H₈₂O₄₁
• Molecular Weight: 1315.14 g/mol
• Melting Point: 267 °C

γ-Cyclodextrin is characterized by its unique toroidal structure, which allows it to form inclusion complexes with various hydrophobic compounds. This property makes it valuable in pharmaceutical applications, particularly for enhancing the solubility and stability of drugs. Its hydrophilic exterior and hydrophobic interior facilitate the encapsulation of active pharmaceutical ingredients, improving their bioavailability and controlled release profiles.

Applications

1. Pharmaceuticals: Used in drug delivery systems to improve the solubility of poorly water-soluble drugs.
2. Food Industry: Acts as a stabilizer and preservative by encapsulating flavors and fragrances.
3. Chemical Analysis: Employed in chromatography as a stationary phase for separating compounds.

Citations:

1. https://en.wikipedia.org/wiki/Cyclodextrin
2. https://pubchem.ncbi.nlm.nih.gov/compound/gamma-Cyclodextrin-hydrate
3. https://www.ottokemi.com/cyclodextrins/C-2774.aspx
4. https://www.thermofisher.com/order/catalog/product/L11271.MC
5. https://www.sigmaaldrich.com/IN/en/product/sigma/c4892
6. https://www.sigmaaldrich.com/IN/en/product/aldrich/861413
7. https://www.mdpi.com/2673-4176/3/1/1
8. https://www.thermofisher.com/order/catalog/product/229900050