Lacto-N-neotetraose (LNnT / neo-LNT)

Lacto-N-neotetraose (LNnT / neo-LNT)

Product Overview

Lacto-N-neotetraose (LNnT) is a well-characterized human milk oligosaccharide (HMO) belonging to the lacto-series neutral glycans. It consists of a tetrasaccharide backbone formed by galactose (Gal), N-acetylglucosamine (GlcNAc), and glucose (Glc) connected through β-glycosidic linkages (Galβ1-4GlcNAcβ1-3Galβ1-4Glc).

LNnT naturally occurs in human breast milk and plays an important biological role as a soluble glycan that mediates microbial recognition and host–microbe interactions. Because of its defined structure and biological relevance, LNnT is widely used as a reference compound in glycobiology, microbiome, and nutrition-related research.

Applications

• Human milk oligosaccharide (HMO) research
• Microbiome and probiotic interaction studies
• Infant nutrition and prebiotic mechanism research
• Pathogen adhesion and inhibition assays
• Lectin and glycan-binding protein studies
• Glycan analytical standards for HPLC, LC-MS, and NMR
• Glycosylation pathway and enzymatic synthesis studies

Key Features

• Structurally defined HMO tetrasaccharide
• Biologically relevant mammalian glycan motif
• Suitable as analytical reference standard
• High purity and reproducibility
• Compatible with ELISA, MS, chromatography, and glycan microarray platforms

Storage & Handling

• Store at −20 °C in a tightly sealed container
• Protect from moisture and prolonged exposure to air
• Allow vial to equilibrate to room temperature before opening