Neu5Acα2-8Neu5Acα2-3Galβ1-4GlcNAc (disialyl lacto-N-triose II or DSLNT II) is a sialylated tetrasaccharide human milk oligosaccharide (HMO) characterized by a unique α2-8 linked disialyl motif where N-acetylneuraminic acid (Neu5Ac) caps another Neu5Acα2-3Gal, extended to the type-2 chain GlcNAc core. This structure, biosynthesized by ST8Sia-II (GD3 synthase) followed by ST3Gal-III/IV on lacto-N-triose II, represents a minor but bioactive HMO fraction (<1% total HMOs) pivotal for neonatal immunity and gut maturation. The terminal α2-8/α2-3 sialyl configuration mimics ganglioside epitopes, serving as high-affinity decoy receptors for sialic acid-binding respiratory/enteric viruses (e.g., influenza, norovirus) and selectins mediating leukocyte trafficking. In prebiotic contexts, it selectively nourishes Bifidobacterium longum subsp. infantis sialidases, modulating microbiota sialometabolism and reducing pathogen adhesion. Therapeutically, synthetic DSLNT II probes Siglec-7/9 inhibitory receptors for cancer immunotherapy, anti-inflammatory glycotherapeutics, and infant formula supplementation to mimic colostrum sialylation patterns protective against necrotizing enterocolitis (NEC).
Source
Molecular Weight and Structure
Sugar Specificity
Biological Activity
Purity and Microbial Contamination
Identity and Quality Control
Shelf Life and Storage
Applications
Key Characteristics
Citation Links
| Size | 10 MG, 25 MG, 50 MG, Other |
|---|
10 in stock
10 in stock
10 in stock
10 in stock
Glycodepot serve all your needs in glycoscience from products, services, networking and announcements. Get the best glycoscience products and services to support your research. Shop Now and learn about cutting-edge solutions in glycochemistry, glycobiology, and glyco-analysis!
