Polystyrene-Linked-4-(1-Hydroxyethyl) 2-methoxy-5-nitrophenol

Polystyrene-linked-4-(1-hydroxyethyl)-2-methoxy-5-nitrophenol

Polystyrene-linked-4-(1-hydroxyethyl)-2-methoxy-5-nitrophenol is a functionalized polymer compound designed for applications in organic synthesis and materials science. This compound features a polystyrene backbone, which provides structural stability and facilitates the attachment of various functional groups.

Structural Characteristics

• Backbone: The polystyrene component offers a robust framework, making the compound insoluble in many organic solvents and suitable for solid-phase reactions.
• Functional Groups:
  • Hydroxyethyl group: Enhances hydrophilicity and provides sites for further chemical modifications.
  • Methoxy group: Contributes to the compound’s solubility and reactivity.
  • Nitrophenol moiety: The nitro group is electron-withdrawing, enhancing the reactivity of the phenolic hydroxyl group, making it suitable for electrophilic substitutions.

Key Properties

• Molecular Formula: C₉H₁₁N₁O₅
• Molecular Weight: Approximately 213.19 g/mol
• Reactivity: Nitro and hydroxyl groups allow for diverse chemical transformations, including coupling reactions and further derivatization.

Applications

• Solid-phase synthesis: Utilized as a support for synthesizing peptides or small molecules, allowing for efficient purification and recovery.
• Photochemical studies: The nitrophenol structure can be employed in photolabile linkers for controlled release applications in biochemical research.

This compound exemplifies the integration of polymer chemistry with functional organic groups, providing a versatile tool for researchers in synthetic chemistry and materials science.

Citations:

1. https://www.chemsrc.com/en/cas/917762-48-2_1083628.html
2. https://www.chemsrc.com/en/cas/182122-17-4_164385.html
3. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB1699531.htm
4. https://pubchem.ncbi.nlm.nih.gov/compound/4-_Hydroxymethyl_-2-methoxy-5-nitrophenol
5. https://www.sigmaaldrich.com/IN/en/product/aldrich/55262
6. https://www.ambeed.com/products/182122-17-4.html
7. https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyethyl-photolinker
8. https://www.sigmaaldrich.com/IN/en/product/enamine/ena497375049?context=bbe