Tridecyl β-D-maltopyranoside

Tridecyl β-D-maltopyranoside

Tridecyl β-D-maltopyranoside (CAS No. 93911-12-7) is a non-ionic surfactant and glycoside that serves as a critical reagent in biochemical research, particularly in studies involving membrane proteins. This compound is characterized by its long hydrophobic tridecyl chain and a maltose moiety, which contribute to its effectiveness as a detergent in various applications.

Chemical Properties

• CAS Number: 93911-12-7
• MDL Number: MFCD08062386
• EINECS: 999-999-2
• Molecular Formula: C25H48O11
• Molecular Weight: 524.64 g/mol
• Boiling Point: Predicted at 688.2 ± 55.0 °C
• Melting Point: Not specified
• Appearance: Typically appears as a white to off-white powder

Structure and Composition

Tridecyl β-D-maltopyranoside consists of:

1. Tridecyl Chain: A hydrophobic tridecyl alkyl group that enhances the compound’s ability to solubilize membrane proteins by interacting with lipid bilayers.
2. Maltose Moiety: The maltose part of the molecule provides hydrophilicity, allowing the compound to function effectively as a surfactant while maintaining protein solubility.
3. Non-Ionic Nature: As a non-ionic detergent, it does not carry a charge, making it less likely to interfere with protein interactions compared to ionic detergents.

Applications

Tridecyl β-D-maltopyranoside is widely used in various applications:

Biochemical Research

1. Membrane Protein Solubilization: It is commonly employed to solubilize membrane proteins for structural studies and crystallization, helping maintain protein stability and function during experiments.
2. Detergent for Crystallization: In studies on membrane protein crystallization, Tridecyl β-D-maltopyranoside has proven effective in maintaining protein solubility, often requiring the presence of salt for optimal results.
3. Enzyme Studies: It can be used in assays to study enzyme kinetics and interactions involving membrane-associated proteins.

Pharmaceutical Development

1. Formulation Development: Its properties make it suitable for developing drug formulations that require the stabilization of membrane proteins or other sensitive biomolecules.

Analytical Chemistry

1. Micellar Electrokinetic Chromatography: Similar compounds have been utilized in analytical techniques such as micellar electrokinetic chromatography for studying enantiomer separation of drugs.

Safety and Handling

While specific safety data for Tridecyl β-D-maltopyranoside are not extensively documented, standard laboratory safety practices should be followed:

1. Personal Protective Equipment (PPE): Use gloves, goggles, and lab coats when handling this compound to avoid skin or eye contact.
2. Ventilation: Work in a well-ventilated area or fume hood to minimize exposure to vapors or dust.
3. Storage Conditions: Store the compound at -20 °C to maintain stability and prevent degradation.
4. Disposal Guidelines: Dispose of waste according to local regulations regarding hazardous materials.

Summary

In summary, Tridecyl β-D-maltopyranoside (CAS No. 93911-12-7) is an essential reagent in biochemical research for studying membrane proteins and facilitating crystallization processes. Its unique structural features enable its use in various applications within the fields of biochemistry and pharmaceutical development.

Citations:

1. https://goldbio.com/product/13709/tridecyl-beta-d-maltopyranoside
2. https://www.sigmaaldrich.com/IN/en/product/sigma/d4641
3. https://file.medchemexpress.com/batch_PDF/HY-W850994/Tridecyl-%CE%B2-D-maltopyranoside-DataSheet-MedChemExpress.pdf
4. https://moleculardepot.com/product/tridecyl-%CE%B2-d-maltoside/
5. https://pubchem.ncbi.nlm.nih.gov/compound/Tridecyl-b-D-maltopyranoside
6. https://anatrace.com/category/t323-n-tridecyl-v-d-maltopyranoside-anagrade
7. https://www.synzeal.com/en/tridecyl-b-d-maltopyranoside
8. https://www.creative-biolabs.com/n-tridecyl-d-maltopyranoside-18095.htm