Varenicline Carbamoyl b-D-Glucuronide

Varenicline Carbamoyl b-D-Glucuronide

Varenicline Carbamoyl β-D-Glucuronide, with the CAS number 535920-98-0, is a significant metabolite of varenicline, a medication primarily used for smoking cessation. Here’s a detailed overview of its properties and characteristics:

Chemical Information

• Molecular Formula: C20_{20}20H21_{21}21N3_{3}3O8_{8}8
• Molecular Weight: 431.40 g/mol
• Melting Point: 181-183°C
• Appearance: Typically exists as a white to off-white solid at room temperature.

Properties and Usage

Varenicline Carbamoyl β-D-Glucuronide is notable for its role in glycobiology research and as a biochemical reagent. It is often utilized in studies related to the pharmacokinetics of varenicline itself, which acts as a partial agonist at nicotinic acetylcholine receptors. This mechanism helps in reducing cravings and withdrawal symptoms associated with smoking cessation.

Storage Conditions

• Recommended Storage:
  • At 2-8°C under inert atmosphere for optimal stability.
  • Can be stored at room temperature for short periods during shipping.

Solubility

The compound may dissolve in solvents such as DMSO, ethanol, or water, depending on the formulation. It is important to prepare stock solutions carefully to maintain stability and effectiveness in experimental settings.

Applications

Varenicline Carbamoyl β-D-Glucuronide is primarily used in:

• Research related to smoking cessation therapies.
• Biochemical assays to understand drug metabolism and efficacy.

This compound serves as an essential reference standard in pharmaceutical testing and research environments, ensuring accurate results in various applications.

Citations:

1. https://www.lgcstandards.com/TH/en/Varenicline-Carbamoyl-beta-D-Glucuronide-d4/p/TRC-V098487?queryID=fad5ceb1fff833da7b640316d6aa194d
2. https://www.invivochem.com/product/V99259
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC2629973/
4. https://www.pharmaffiliates.com/en/535920-98-0-varenicline-carbamoyl-beta-d-glucuronide-pa2218740.html
5. https://www.bocsci.com/product/varenicline-carbamoyl-glucuronide-cas-535920-98-0-2295.html
6. https://www.biosynth.com/p/MV16890/535920-98-0-varenicline-carbamoyl-b-d-glucuronid
7. https://www.simsonpharma.com/us/product/varenicline-carbamoyl-beta-d-glucuronide
8. https://www.medchemexpress.com/varenicline-crbamoyl-%CE%B2-d-glucuronide.html