Wogonoside

Wogonoside

Wogonoside (CAS No. 51059-44-0) is a flavonoid glycoside derived from the roots of Scutellaria baicalensis, a plant known for its medicinal properties. This compound is recognized for its various biological activities, including anti-inflammatory, antioxidant, and potential anticancer effects.

Chemical and Physical Properties

• CAS Number: 51059-44-0
• MDL Number: MFCD08704808
• EINECS: Not specified
• Molecular Formula: C₂₂H₂₀O₁₁
• Molecular Weight: 460.39 g/mol
• Boiling Point: 820.7°C at 760 mmHg
• Melting Point: 226–227°C
• Density: 1.629 g/cm³
• Appearance: Odorless gray-brown powder

Structure and Composition

Wogonoside consists of a flavonoid backbone with multiple hydroxyl groups and a glucuronide moiety. This structure contributes to its solubility and biological activity, enhancing its interaction with cellular targets.

Biological Activity and Applications

1. Anti-inflammatory Properties: Wogonoside has been shown to inhibit inflammation by modulating various signaling pathways, making it a candidate for treating inflammatory diseases.
2. Antioxidant Effects: It exhibits strong antioxidant activity, helping to protect cells from oxidative stress and damage caused by free radicals.
3. Anticancer Potential: Research suggests that Wogonoside may inhibit cancer cell proliferation and induce apoptosis in various cancer types, including breast cancer.
4. Neuroprotective Effects: It has been studied for its potential to protect neuronal cells from damage, indicating possible applications in neurodegenerative diseases.

Production and Extraction

Wogonoside is typically extracted from the roots of Scutellaria baicalensis using solvent extraction methods. Its purity can be enhanced through chromatographic techniques.

Safety and Handling

Wogonoside is generally considered safe for use in research and therapeutic applications; however, standard laboratory safety protocols should be followed when handling the compound.

Storage Recommendations

For long-term stability, Wogonoside should be stored at temperatures between 2–8°C in a cool, dry place away from light.

In summary, Wogonoside is a valuable flavonoid glycoside with significant therapeutic potential due to its anti-inflammatory, antioxidant, and anticancer properties. Its extraction from traditional medicinal plants highlights its importance in both natural product chemistry and pharmacology.

Citations:

1. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB4839835.htm
2. https://www.tcichemicals.com/IN/en/p/W0012
3. https://www.sigmaaldrich.com/IN/en/product/sigma/smb00081
4. https://www.chemfaces.com/natural/Wogonoside-CFN99710.html
5. https://www.biocrick.com/Wogonoside-BCN1200.html
6. https://www.lgcstandards.com/IT/en/p/CDX-00023515
7. https://www.sigmaaldrich.com/US/en/product/ambeedinc/ambh9a9adcc0?context=bbe
8. https://www.abmole.com/products/wogonoside.html