1-Naphthylglucuronide

1-Naphthyl b-D-glucuronide 1-Naphthyl ?-D-glucuronide (1NG) is a glucuronide conjugate that is used as an experimental model to study the transport of drugs across cell membranes. 1NG has been shown to inhibit the activity of p-glycoprotein, which may be due to its ability to bind to the ATP binding site on this transporter. 1NG inhibits the uptake of carbaryl and dinucleotide phosphate by primary cells, which could be due to its ability to inhibit enzyme activities. This compound also interacts with other drugs, such as atenolol and erythromycin, which can lead to drug interactions. CAS Number 17238-47-0 Product Name 1-Naphthyl glucuronide IUPAC Name (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-naphthalen-1-yloxyoxane-2-carboxylic acid Molecular Formula C16H16O7 Molecular Weight 320.29 g/mol InChI InChI=1S/C16H16O7/c17-11-12(18)14(15(20)21)23-16(13(11)19)22-10-7-3-5-8-4-1-2-6-9(8)10/h1-7,11-14,16-19H,(H,20,21)/t11-,12-,13+,14-,16+/m0/s1 InChI Key KEQWBZWOGRCILF-JHZZJYKESA-N SMILES C1=CC=C2C(=C1)C=CC=C2OC3C(C(C(C(O3)C(=O)O)O)O)O Synonyms 1-naphthol-beta-D-glucuronide, 1-naphthyl glucuronide, naphthyl glucuronide, naphthyl glucuronide, (beta-D)-isomer, naphthyl glucuronide, monosodium salt Canonical SMILES C1=CC=C2C(=C1)C=CC=C2OC3C(C(C(C(O3)C(=O)O)O)O)O Isomeric SMILES C1=CC=C2C(=C1)C=CC=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C(=O)O)O)O)O