4-Methylumbelliferyl-beta-D-glucopyranoside

4-Methylumbelliferyl-BETA-D-glucopyranoside, 4-Methylumbelliferyl bD-glucopyranoside 4-Methylumbelliferyl-?-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of ?-glucosidase and ?-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel ?-glucosidases, 4-MUG is used in assays to evaluate deficiency in ?-glucocerebrosidase activity related to Gaucher disease. Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent : 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. CAS Number 18997-57-4 Product Name 4-Methylumbelliferyl glucoside IUPAC Name 4-methyl-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one Molecular Formula C16H18O8 Molecular Weight 338.31 g/mol ikB InChI=1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19) 11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16-/m1/s1 InChI Key YUDPTGPSBJVHCN-YMILTQATSA-N SMILES CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)O Synonyms 4-methylumbelliferyl glucoside, 4-methylumbelliferyl glucoside, (alpha)-isomer, 4-methylumbelliferyl-alpha-D-glucopyranoside, 4-methylumbelliferyl-beta-D-glucopyranoside, 4-MU-alpha-glucoside, 4-MU-glucoside, MUbetaGlu Canonical SMILES CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)O Isometric SMILES CC1=CC(=O)OC2=C1C=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3 )CO)O)O)O CAS No: 18997-57-4 Synonyms: 4-MU-bD-GlcMUD MDL No: MFCD00063694 Chemical Formula: C16H18O8 Molecular Weight: 338.31 white to off-white crstalline powder.In Stock.In Stock. References: 1. Mikhaylova M, Wiederschain G, Mikhaylov V, Aerts JM, Biochem. Biophys. Acta 1996, 1317, p712. Setlow B, Cabrera-Martinez RM, Setlow P, J. Appl. Microbiol. 2004, 96, p1245