4-METHYLUMBELLIFERYL2-ACETAMIDO-2-DEOXY-ALPHA-D-GALACTOPYRANOSIDE

4-Methylumbelliferyl 2-acetamido-2-deoxy-a-D-galactopyranoside A fluorogenic substrate for the detection of lysosomal enzyme N-acetyl-?-D-galactopyranosiaminidase (NAGA), which is driving the pathogenesis of Schindler disease. Also substrate for endo-?-N-acetylgalactosaminidase (O-glycosidase), which cleaves O-linked core 1 and core 3 disaccharides from glycoproteins. 4-Methylumbelliferyl 2-acetoamido-2-deoxy-?-D-galactopyranoside (4-MU-2-acetoamido-2-deoxy-?-Gal) is a fluorogenic substrate used to quantify ?- and ?-galactopyranosaminidase activity. 4-MU-2-acetoamido-2-deoxy-?-Gal is cleaved by ?- and ?-galactopyranosaminidase to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. CAS Number 124223-99-0 Product Name 4-Methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-galactopyranoside IUPAC Name N-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]acetamide Molecular Formula C??H??NO? Molecular Weight 379.36 InChI InChI=1S/C18H21NO8/c1-8-5-14(22)26-12-6-10(3-4-11(8)12)25-18-15(19-9(2)21)17(24)16(23)13(7-20)27-18/h3-6,13,15-18,20,23-24H,7H2,1-2H3,(H,19,21)/t13-,15-,16+,17-,18+/m1/s1 SMILES CC1=CC(=O)OC2=C1C=CC(=C2)OC3C(C(C(C(O3)CO)O)O)NC(=O)C Synonyms 7-[[2-(Acetylamino)-2-deoxy-?-D-galactopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one; GalNAc1-?-4MU; CAS No: 124223-99-0 Synonyms: GalNAc-a-4MUANAGA4MU N-acetyl-a-D-galactosaminide4-Methylumbelliferyl N-acetyl-a-D-galactosaminide MDL No: MFCD00270047 Chemical Formula: C18H21NO8 Molecular Weight: 379.36