Methoxyresorufin

Resorufin methyl ether 7-Methoxy-3H-phenoxazin-3-one; 7-Methoxyresorufin; Resorufin 7-O-methyl ether Fluorogenic substrate used to differentiate cytochrome P450 monooxygenases. Fluorometric competitive cytochrome P450 substrate. Resorufin butyrate analog. Shows selectivity for CYP1A (Ki = 20 ?M, dealkylation 0.5 ?M substrate). Methoxyresorufin is a fluorogenic substrate for the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2.1,2,3 Methyoxyresorufin is O-demethylated by CYP1A1/2, releasing resorufin, which displays excitation/emission maxima of 570/580 nm, respectively. The appearance of resorufin fluorescence can be used to quantify CYP1A1/2 activity. CAS Number 5725-89-3 Product Name Methoxyresorufin IUPAC Name 7-methoxyphenoxazin-3-one Molecular Formula C13H9NO3 Molecular Weight 227.22 g/mol InChI InChI=1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3 InChI Key KNYYMGDYROYBRE-UHFFFAOYSA-N SMILES COC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2 Synonyms 7-Methoxy-3H-phenoxazin-3-one; 7-Methoxyphenoxazone; Methoxyresorufin; O-Methylresorufin; Resorufin Methyl Ether Canonical SMILES COC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2