α-1,3/4-fucosyltransferase

α-1,3/4-fucosyltransferase Accepted Name 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase. Alternative Name(s) (Le(a))-dependent (alpha-3/4)-fucosyltransferase. Alpha(1,3/1,4) fucosyltransferase III. Alpha-(1->4)-L-fucosyltransferase. Alpha-4-L-fucosyltransferase. Beta-acetylglucosaminylsaccharide fucosyltransferase. Blood group Lewis alpha-4-fucosyltransferase. Blood-group substance Le(a)-dependent fucosyltransferase. FucT-II. Galactoside 3(4)-L-fucosyltransferase. Guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L- fucosyltransferase. Guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase. Guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase. Lewis alpha-(1->3/4)-fucosyltransferase. Lewis blood group alpha-(1->3/4)-fucosyltransferase. Lewis FT. Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase. Reaction catalysed GDP-beta-L-fucose  +  beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R  <=>  GDP  +  beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R Comment(s) Product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see CA line) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity toward the glucose residue in free lactose. Fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC  2.4.1.152  which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalyzing the 4-alpha-fucosylation of the GlcNAc in beta-D- Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha- fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities. Documents: CoA