UDP-3-F-D-Glc.2Na

UDP-3-F-D-Glc.2Na UDP-3-F-D-Glucose UDP-3-F-D-Glc.2Na, Uridine 5?-disphospho-3-fluoro-D-glucose disodium salt UDP-3-F-D-Glc.2Na (Uridine Diphosphate 3-Fluoro-D-Glucose disodium salt) is a fluorinated nucleotide sugar, where the hydroxyl group at the 3-position of glucose is replaced by a fluorine atom. This modification imparts unique chemical properties that make it valuable in glycosylation research and the development of synthetic glycans with specific biological properties. Structure & Properties: Molecular Weight (MW): Approximately 586 g/mol (depending on the specific form and substitutions) Chemical Formula: C15H22FNO17P2Na2 (approximate) Synonyms: UDP-3-fluoro-D-glucose, Uridine Diphosphate 3-fluoro-D-glucose disodium salt Functional Groups: The glucose moiety is modified with a fluorine atom at the 3-position, altering its reactivity and interaction with biological enzymes compared to native glucose. Biological Role: Biosynthesis Pathway: UDP-3-F-D-Glc is synthesized by the fluorination of UDP-glucose at the 3-position. It is used as a glycosyl donor in glycosylation processes, participating in the transfer of sugar molecules during the formation of glycans. Function: This modified sugar is employed in studies of enzyme specificity, particularly in glycosyltransferases that interact with sugar nucleotides during glycan synthesis. Applications: Glycosylation Research: UDP-3-F-D-Glc is a research tool for investigating how modifications such as fluorination affect glycan biosynthesis. It helps in the understanding of enzyme-substrate interactions within glycosylation pathways. Biotechnology and Drug Design: Fluorinated sugars like UDP-3-F-D-Glc are explored in the development of new drugs, particularly those that target enzymes involved in glycosylation or in the creation of synthetic glycomimetics. Research Significance: Fluorinated Sugar Nucleotides: The presence of fluorine in biological molecules often enhances their stability and resistance to enzymatic degradation, which makes UDP-3-F-D-Glc a useful molecule for studying glycosylation pathways. Enzyme Inhibition and Modification: UDP-3-F-D-Glc can be used to explore the inhibition of glycosyltransferases or to synthesize altered glycan structures with potential therapeutic applications. Storage and Stability: Storage: UDP-3-F-D-Glc should be stored at -20°C in a dry, moisture-free environment. Stability: The compound remains stable under recommended storage conditions, but exposure to light, heat, or moisture should be avoided to prevent degradation. Research Areas: Glycan Synthesis and Enzyme Mechanisms: Researchers use UDP-3-F-D-Glc to study the mechanisms by which glycosyltransferases incorporate sugar molecules into glycans and how fluorinated sugars impact these processes. Therapeutic and Diagnostic Development: This compound holds potential for therapeutic development, particularly in areas involving glycan-based therapies or diagnostics. Conclusion: UDP-3-F-D-Glc.2Na is a valuable fluorinated nucleotide sugar used in the study of glycosylation and enzyme specificity. Its unique properties make it a powerful tool in glycoscience, with potential applications in biotechnology, drug discovery, and synthetic biology.