Validamine

Validamine

Validamine is a chemical compound that serves as an important intermediate in the synthesis of various bioactive molecules, particularly in the field of agriculture and pharmaceuticals. It is recognized for its structural similarity to validamycin, a known antibiotic with antifungal properties.

Chemical Properties

• CAS Number: 32780-32-8
• MDL No.: MFCD08063357
• Catalog Number: A821410
• EINECS: 614-004-0
• Molecular Formula: C₇H₁₅NO₄
• Molecular Weight: 191.22 g/mol
• Boiling Point: 345.6 ± 42.0 °C
• Melting Point: Not specified
• Flash Point: Not specified
• Density: 1.434 ± 0.06 g/cm³
• Appearance: Typically a white crystalline powder (exact appearance not specified)
• Storage Conditions: Store at 2–8 °C for long-term stability (months).

Applications

1. Agricultural Use:
   • Validamine is utilized in the synthesis of validamycin, which is an effective antifungal agent used in agriculture to control various fungal diseases in crops.
2. Pharmaceutical Development:
   • It serves as a precursor in the development of antibiotic compounds, contributing to the discovery of new therapeutic agents against bacterial infections.
3. Biochemical Research:
   • Validamine is studied for its potential roles in inhibiting specific enzymes and pathways, making it relevant in research focused on metabolic processes and disease mechanisms.
4. Synthetic Chemistry:
   • It is employed as an intermediate in organic synthesis, particularly in the preparation of glycosides and other carbohydrate derivatives.

Mechanism of Action

Validamine and its derivatives function primarily by interfering with microbial cell wall synthesis or metabolic pathways, thus exerting their antimicrobial effects. The structural features of validamine allow it to mimic natural substrates involved in these processes, enhancing its efficacy as an inhibitor.

Safety Profile

While specific safety data for validamine may be limited, standard laboratory safety protocols should be followed when handling this compound. Appropriate personal protective equipment (PPE) should be used to minimize exposure.

Conclusion

Validamine (CAS No. 32780-32-8) is a significant compound in agricultural and pharmaceutical applications due to its role as a precursor for validamycin and other bioactive molecules. Its properties make it essential for research and development in combating fungal infections and studying biochemical pathways.

Citations:

1. https://www.chemsrc.com/en/cas/37248-47-8_1195744.html
2. https://www.chemsrc.com/en/cas/38231-86-6_330036.html
3. https://pubchem.ncbi.nlm.nih.gov/compound/Validamycin-A
4. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB4745725.htm
5. https://www.guidechem.com/encyclopedia/validamycin-dic23050.html
6. https://www.medkoo.com/products/14050
7. https://www.chemnorm.com/Product/Validamine-TBZ2987.html
8. https://www.guidechem.com/dictionary/en/37248-47-8.html