Galactose PEG Succinimidyl Carboxymethyl Ester

Galactose PEG Succinimidyl Carboxymethyl Ester with superior quality specification of ≥90% Substitution. Galactose PEG Succinimidyl Carboxymethyl Ester is a  high quality amine reactive PEG product with a succinimidyl carboxymethyl ester reactive group and a targeting galactose group. Galactose PEG SCM reacts with amino group of lysine(s) at room temperature in under 1hr, at pH 7-8. The presence of the galactose monosaccharide increases significantly the selectivity of the PEGylation reaction. References: Luan, J., et al., GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis, Biomaterials, 2020, V. 227. He, H., et al., Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis, Translational Research, 2018, 193, P. 13-30. He, H., et al., Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis, Biomaterials, 2017, 130:1-3. Weaver, E.A., et al., Effects of Shielding Adenoviral Vectors with Polyethylene Glycol on Vector-Specific and Vaccine-Mediated Immune Responses, Human Gene Therapy, 2008, 19:1369–1382.