Glucose PEG Succinimidyl Carboxymethyl Ester

Glucose PEG Succinimidyl Carboxymethyl Ester is a high quality amine reactive PEG product with a succinimidyl carboxymethyl ester active group and a targeting glucose group. Glucose PEG Succinimidyl Carboxymethyl Ester reacts with amine group of lysine(s) at room temperature in less than 1hr, at pH 7-8. The presence of the monosaccharide sugar group (Glucose) increases significantly the selectivity of the PEGylation reaction. References: Wei, G, et al., Glucose Transporter 1 (GLUT1)-Targeting and Hypoxia-Activated Mitochondria-Specific Chemo-thermal Therapy via a Glycosylated Poly (amido amine)/Celastrol (PAMAM/Cel) Complex. Journal of Colloid and Interface Science. 2021. He, H., et al., Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis, Translational Research, 2018, Vol. 193, P. 13-30. Drappier, C., pH-Responsive Surface Shielding By Electrostatic Adsorption of PEG Segments With Anionic Chain End, Universite Bordeaux, 2013. Weaver, E.A., et al., Effects of Shielding Adenoviral Vectors with Polyethylene Glycol on Vector-Specific and Vaccine-Mediated Immune Responses, Human Gene Therapy 2008, 19:1369–1382.