Alkyne-modified nucleotide sugar donor substrate for GalNAc-transferases (ppGalNAcTs) and O-GlcNAc transferase (OGT); enables bioorthogonal click chemistry labeling of O-GalNAc glycans and O-GlcNAcylated proteins via copper-catalyzed azide–alkyne cycloaddition (CuAAC); used for glycoproteomic profiling, glycan imaging, and metabolic labeling
Alkyne-modified nucleotide sugar donor substrate; used for remodeling of cell-surface glycans and O-GlcNAc profiling; the terminal alkyne handle enables bioorthogonal detection via copper-catalyzed azide–alkyne cycloaddition (CuAAC); less susceptible to epimerization than the corresponding GalNAc analog; applied in glycoproteomic profiling, glycan imaging, and metabolic labeling
Uridine-5’-diphospho-6-azido-6-deoxy-D-glucose, Disodium Salt
Synonyms
UDP-6-N3-Glc·2Na, UDP-α-6N3-Glucose Disodium Salt, UDP-6-Azido-6-deoxy-D-Glucose Disodium Salt
Molecular Formula
C15H21N5O16P2 · 2Na
Molecular Weight
635.28 g/mol (disodium salt)
CAS No.
537039-67-1
Appearance
White to off-white lyophilized powder
Purity
≥95% (HPLC)
Solubility
Soluble in water
Storage
−20°C, protect from moisture and light
Application
Azido-modified nucleotide sugar donor substrate for glucosyltransferases; the C6-azido handle enables bioorthogonal detection via copper-catalyzed azide–alkyne cycloaddition (CuAAC) and strain-promoted azide–alkyne cycloaddition (SPAAC); used for selective labeling of 5-hydroxymethylcytosine (5-hmC) in genomic DNA, glycan imaging, and glycoproteomic profiling