Functional Groups: The key feature of UDP-6-N3-GlcNAc is the azide group (-N3) at the 6th position of the GlcNAc sugar, which is commonly used for bioorthogonal chemical reactions.
Activated nucleotide sugar donor substrate for UDP-glucuronosyltransferases (UGTs); essential for Phase II glucuronidation metabolism of xenobiotics and endogenous compounds; also serves as a donor for glycosaminoglycan (GAG) biosynthesis (heparan sulfate, chondroitin sulfate, hyaluronic acid) and plant cell-wall polysaccharide assembly