D-Saccharicacid1,4-lactonemonohydrate

D-Glucaric acid-1,4-lactone D-Saccharic acid 1,4-lactone monohydrate (DSAL) has an ability to inhibit the activity of ?-glucuronidase enzyme. It also potentially inhibits Klotho deglycosylation of excitatory amino acid transporters (EAATs) and peptide transporters (PEPTs). D-Saccharic acid 1,4-lactone is an inhibitor of ?-glucuronidase (IC50 = 45 ?M for the human enzyme). It is commonly used as a standard in the development of novel inhibitors of ?-glucuronidase. D-Saccharic Acid 1,4-lactone is also used to prevent the cleavage of glucuronides in plasma, serum, or urine by ?-glucuronidase in samples. CAS Number 61278-30-6 Product Name (S)-2-((2S,3R,4R)-3,4-Dihydroxy-5-oxotetrahydrofuran-2-yl)-2-hydroxyacetic acid hydrate IUPAC Name (2S)-2-[(3R,4R)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetic acid;hydrate Molecular Formula C6H10O8 Molecular Weight 210.14 g/mol InChI InChI=1S/C6H8O7.H2O/c7-1-2(8)6(12)13-4(1)3(9)5(10)11;/h1-4,7-9H,(H,10,11);1H2/t1-,2-,3+,4?;/m1./s1 InChI Key NPFKVZHSFSFLPU-QGBSHYGGSA-N SMILES C1(C(C(=O)OC1C(C(=O)O)O)O)O.O Synonyms 1,4-Lactone-D-glucaric Acid Monohydrate; Canonical SMILES C1(C(C(=O)OC1C(C(=O)O)O)O)O.O Isomeric SMILES [C@H]1([C@H](C(=O)O[C@@H]1[C@@H](C(=O)O)O)O)O.O CAS No: 61278-30-6 Synonyms: D-SaccharolactoneD-Saccharic acid 1,4-lactone monohydrate MDL No: MFCD00149334 Chemical Formula: C6H8O7?H2O Molecular Weight: 210.14 white to off-white crystalline powder